Fig. 1

Localization of TP53 mutations in GC samples from Eastern Europe, China, and Japan (exons 4 to 8). Mutation-distribution maps were created using the cBioPortal mutation mapper (http://www.cbioportal.org/mutation_mapper). Black dots indicate truncating mutations (nonsense and frameshift mutations). Missense mutations were prevalent in all three groups. Some mutation assemblies, including R175H/G and R273C/H/P, were observed in 5-10 cases in each group. P53_TAD, TP53 transcriptional activation domain; P53, TP53 DNA-binding domain; P53 tetramer, TP53 tetramer domain