Fig. 2

TP53 mutation assemblies in each exon (exons 4 to 8) in GC samples from Eastern Europe, China, and Japan. TP53 mutation assemblies in each exon (exons 4 to 8) are shown as ratios of the number of GC mutations in each exon to the total number of mutations in exons 4 to 8 in each group. The blue, orange, and gray bars indicate the TP53 assembly of each exon in GC samples from Eastern Europe, China, and Japan, respectively. In Eastern Europe, TP53 mutations were particularly noted in exons 5 and 8. The prevalence of exon 4 mutations was low in Japanese patients. In Chinese patients, the mutations were relatively evenly distributed among exons 4 to 8. The exon distribution of TP53 mutations was significantly different in Eastern Europe, China, and Japan (χ² test for three regions by five exons; p < 0.05)