Fig. 3

TP53 mutation types in GC samples from Eastern Europe, China, and Japan (exons 4 to 8). Missense mutations were the most prevalent type (60% of all the mutations) in all the areas. The pie graphs show the percentages of the mutation functions, including missense (blue), nonsense (orange), and silent mutations (gray), deletions (del) (yellow), deletion-insertion (delins) (light blue), insertion (ins) (light green), and splice site mutations (dark blue) in TP53 in GC samples from Eastern Europe, China, and Japan. All three groups showed similar ratios for each type of mutation. The prevalence of silent mutations (grey) was significantly different between Europe and Asia (p < 0.01). * Statistically significant difference (p < 0.05)