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Fig. 4 | Genes and Environment

Fig. 4

From: Non-CpG sites preference in G:C > A:T transition of TP53 in gastric cancer of Eastern Europe (Poland, Romania and Hungary) compared to East Asian countries (China and Japan)

Fig. 4

TP53 mutation spectra in GC samples from Eastern Europe, China, and Japan. The TP53 mutations in the spectrum were classified into six types of single nucleotide substitutions, as well as deletions (del), insertions (ins), deletion-insertion (delins), and splice mutations. The G:C > A:T transitions were subdivided into G:C > A:T at CpG and non-CpG sites. Each spectrum is shown in the pie graph as follows: G:C > A:T at CpG sites (blue), G:C > A:T at non-CpG sites (orange), A:T > G:C (gray), G:C > C:G (yellow), G:C > T:A (light blue), A:T > C:G (light green), A:T > T:A (dark blue), del (brown), delins (dark gray), ins (light brown), and splice mutations (light navy). The percentages of G:C > A:T transitions at CpG sites were almost equivalent in Eastern Europe, China, and Japan. Those at non-CpG sites showed a significantly higher percentage in Eastern Europe than in East Asian countries. The prevalence of G:C > A:T at non-CpG sites (orange) and A:T > G:C (gray) in Asia was also significantly different from that in Eastern Europe (p < 0.05). * Statistically significant difference (p < 0.05)

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