Fig. 5

TP53 mutation spectra in Caucasian and Asian populations in TCGA. The TP53 mutations in the spectrum were classified into six types of single nucleotide substitutions, as well as deletions (del), insertions (ins), deletion-insertion (delins), and splice mutations. The G:C > A:T transition was subdivided into G:C > A:T at CpG and non-CpG sites. Each spectrum is shown in the pie graph as follows: G:C > A:T at CpG sites (blue), G:C > A:T at non-CpG sites (orange), A:T > G:C (gray), G:C > C:G (yellow), G:C > T:A (light blue), A:T > C:G (light green), A:T > T:A (dark blue), del (brown), delins (dark gray; 0% in both populations), ins (light brown), and splice mutations (light navy)