Table 3 Newly identified TP53 mutations

Hungary

c.97-39G > A

intron

substitution

Intron 3

c.99_100insGTCC

p.(Pro34Valfs*10)

ins

Exon 4

Poland

c.484_488delinsC

p.(Ile162Profs*7)

delins

Exon 5

c.672 + 83 T > C

intron

substitution

Intron 6

Romania

c.412_422del

p.(Ala138Profs*7)

del

Exon 5

c.450_478del

p.(Pro151Glyfs*20)

del

Exon 5

c.622_623insGATA

p.(Asp208Glyfs*2)

ins

Exon 6

c.672 + 3C > T

p.?

substitution

Intron 6

c.782 + 23G > A

p.?

substitution

Intron 7

c.*1C > T

p.(=)

substitution

3′-UTR (Exon 11)

China

c.323_339del

p.(Gly108Valfs*35)

del

Exon 4

c.98_99insAGTC

p.(Pro34Valfs*10)

ins

Exon 4

c.255_265del

p.(Ala86Leufs*59)

del

Exon 4

c.369_375del

p.(Cys124Thrfs*44)

del

Exon 4

c.195_235del

p.(Arg65Serfs*70)

del

Exon 4

c.646_647insTAG

p.(Val218dup)

ins

Exon 6

c.729_732del

p.(Gly244Alafs*2)

del

Exon 7

c.820_825dup

p.(Val274_Cys275dup)

dup

Exon 8

Japan

c.99_112del

p.(Pro34Serfs*4)

del

Exon 4

c.503_541del

p.(His168_Glu180del)

del

Exon 5

c.514_532del

p.(Val172Thrfs*69)

del

Exon 5

c.449_459del

p.(Thr150Argfs*27)

del

Exon 5

c.473_474delinsCT

p.(Arg158Pro)

delins

Exon 5

c.576_599del

p.(Gln192_Asn200delinsHis)

del

Exon 6

c.588_589del

p.(Val197Glyfs*11)

del

Exon 6

c.755_757delinsCT

p.(Leu252Profs*93)

delins

Exon 7

c.776_782 + 1dup

p.?

splice site^a

Intron 7

c.97-23_97-13del

p.?

splice site^b

Intron 3