Fig. 3
From: Environmental impact on carcinogenesis under BRCA1 haploinsufficiency
Current understanding of ferroptosis, catalytic Fe(II)-dependent regulated necrosis associated with lipid peroxidation. Ferroptosis is three dimensionally regulated by Fe, S and O. Transition to high Fe/S ratio by certain stimulus (Ex. excess iron and erastin [inhibitor of cystine/glutamate antiporter]) to cells initiate uncontrollable lipid peroxidation, which is cellular catalytic Fe(II) dependent and designated as ferroptosis. Ferroptotic cells reveal the morphology of necrosis. ACSL4, acyl-CoA synthatase long-chain 4; GPX4, glutathione peroxidase-4; PUFAs, polyunsaturated fatty acids