Skip to main content
Fig. 2 | Genes and Environment

Fig. 2

From: Short-term in vivo testing to discriminate genotoxic carcinogens from non-genotoxic carcinogens and non-carcinogens using next-generation RNA sequencing, DNA microarray, and qPCR

Fig. 2

Principal component analysis (PCA) of the gene expression levels in mouse liver after a single shot between genotoxic and non-genotoxic hepatocarcinogens as quantified by qPCR. A 4 h with 7 genes (Btg2, Ccnf, Ccng1, Lrp1, Mbd1, Phlda3, and Tubb2c), B 48 h with 12 genes (Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Gdf15, Lrp1, Mbd1, Phlda3, Plk2, and Tubb2c). GTHCs (red-colored, DIPN: diisopropanolnitrosamine, NNK: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, NNM: N-nitrosomorpholine, QN: quinoline, DAT: 2,4-diaminotoluene, DAB: 4-dimethylaminoazobenzene, 2AAF: 2-acetylaminofluorene, URE: urethane) and NGTHCs (bleu-colored, FUR: furan, DDT: dichlorodiphenyltrichloroethane, DEHP: di(2-ethylhexyl)phthalate, DCB: 1,4-dichlorobenzene). A dashed line is added between genotoxic and non-genotoxic hepatocarcinogens [41]

Back to article page