Fig. 3

Principal component analysis (PCA) of the gene expression levels under treatment with 3 types of carcinogens in rat liver as quantified by qPCR. GTHCs (red-colored, DEN-L: DEN low dose, DEN-M: DEN middle dose, DEN-H: DEN high dose, DNT-L: DNT low dose and DNT-H: DNT high dose), an NGTHC (green-colored, DEHP-L: DEHP low dose and DEHP-H: DEHP high dose), and an NGTNHC (blue-colored, PNT-L: PNT low dose and PNT-H: PNT high dose). A 4 h, with 16 genes (Ccnf, Ccng1, Cyp4a1, Ddit4l, Egfr, Gadd45g, Gdf15, Hspb1, Ighbp1, Jun, Myc, Net1, Phlda3, Pml, Rcan1, and Tubb2c), B 48 h, with 10 genes (Aen, Ccng1, Cdkn1a, Cyp21a1, Cyp4a1, Gdf15, Igfbp1, Mdm2, Phlda3, and Pmm1). PCA successfully differentiated GTHCs (red circle) from an NGTHC (green circle) and an NGTNHC (blue circle) with principal component 1 at 4 and 48 h [43]