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Fig. 5 | Genes and Environment

Fig. 5

From: Short-term in vivo testing to discriminate genotoxic carcinogens from non-genotoxic carcinogens and non-carcinogens using next-generation RNA sequencing, DNA microarray, and qPCR

Fig. 5

Analysis by RNA-Seq in rat liver after 28 days of repeated treatment. Discrimination of typical GTHCs (DEN and DMB) to a typical NGTHC (DEHP) and DO by PCA. The mean of each control group was calculated as 0 (log2) and ratio (exp/cont) log2 was calculated. GTHCs (DEN, orange and DMB, brown) were differentiated from DEHP (blue) with PC1. DO (pale blue) was differentiated from typical GTHCs (DEN and DMB) and a typical NGTHC (DEHP). DEN: N-nitrosodiethylamine, DMB: 3,3-dimethylbenzidine·2HCl, DEHP: di(2-ethylhexyl)phthalate, and DO: 1,4-dioxane [8]

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Genes and Environment

ISSN: 1880-7062

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