Fig. 6

PCA analysis of the results of RNA-Seq experiment together with our previous analysis of public data from TG-GATEs [47]. DEN* (dark orange), DMB* (brown), DEHP* (blue), and DO* (pale blue) are from the RNA-Seq experiment. Four typical GTHCs [DEN* (RNA-Seq, dark orange), DMB* (RNA-Seq, light brown), DEN (TG-GATEs, dark brown), and AAF (GT-GATEs, dark brown)] were clearly discriminated from eight NGTHCs [DEHP* (RAN-Seq, blue) and 7 NGTHCs [(TG-GATEs, blue), clofibrate, ethanol, fenofibrate, gemfibrozil, hexachlorobenzene, phenobarbital, and WY-14613] plus 10 NGTNHCs [(TG-GATEs, blue), allyl alcohol, aspirin, caffeine, chlorpheniramine, chlorpropamide, diazepam, indomethacin, phenylbutazone, theophylline, and tolbutamide] with PC1. However, DO* (pale blue) from RNA-Seq data may be intermediate between typical GTHCs and the group of typical NGTHCs plus NGTNHCs. Each point shows the mean of five animals for RNA-Seq [8] and three animals for TG-GATEs [47]