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Table 2 NGTHC biomarker candidates in mouse liver proposed by Kossler et al. [46]

From: Short-term in vivo testing to discriminate genotoxic carcinogens from non-genotoxic carcinogens and non-carcinogens using next-generation RNA sequencing, DNA microarray, and qPCR

Up-regulated genes by NGTHC:

Cell cycle progression:

Hnf4aos (0610008F07Rik), Nsl1, Rorc

Apoptosis:

Pgap2

Detoxicification response:

Ces2a, Cyp2c250, Cyp2c65, Gstm1

Cellular assembly and organization:

Nebl

Others:

Akr1d1, Atosa, Atxn10, Dgka, Fam171a1, Fndc5,

 

Ginm1 (BC013529Rik), Gm10419, Gm2011, Pnliprp1,

 

Tulp2, Zkscan14, 2810433D01Rik, 4930597L12Rik, 4931406C07Rik

Down-regulated genes by NGTHC:

DNA damage response:

Armt1

Cell cycle progression:

Aigl, Atad2, Fgl1, Mcm5, Ncapg2, Pola1, Prkd2, Tead1

Apoptosis:

Nolc1, Tnfrsf1b

Cellular assembly and organization:

Pkp2

Immune response:

Cebpb

Others:

Camkk2, Coa6 (1810063B05Rik), Gnat1, Grhl1, Grk3, Gtf2b, Hip1r,

 

Nr2c2, Pla2g16, Prdm15, Rasal2, Samd4a, Slc25a32, Tmem98,

 

 Tmem181c-ps, Tmem268, Zfp472, Zfp750, A930036K24Rik,

 

 2310075K07Rik, 5430416B10Rik,