Mutation and apoptosis are well-coordinated for protecting against DNA damage-inducing toxicity in Drosophila

Genes and Environment

Table 4 Apoptosis and mutation induced by exposure to cigarette smoke (CS) for 6 h in wild-type Drosophila (Oregon-R) and oxidative damage-sensitive strain Drosophila (y v ma-l)

Strain	Oregon-R		y v ma-l
Time of exposure to CS	0	6 h	0	6 h
Apoptosis (number of clusters stained with AO/disc) ^a
Time post-exposure (h)
0	26.9 ± 11.3	24.1 ± 12.5	30.6 ± 10.9	19.0 ± 8.2
6	22.7 ± 9.6	27.7 ± 21.6	26.3 ± 13.8	41.3 ± 29.6
12	19.9 ± 5.8	23.2 ± 13.7	22.1 ± 9.7	41.4 ± 19.9
18	21.3 ± 8.7	26.9 ± 11.0	19.1 ± 8.2	32.4 ± 14.6
24	18.4 ± 9.5	24.0 ± 13.2	21.5 ± 9.2	24.8 ± 9.4

a: The number of discs scored was 30. Ten discs were counted for each experiment, and three independent experiments were performed

ISSN: 1880-7062