Table 1 Effect of well-studied clastogens and aneugen on micronucleus induction and cytotoxicity
From: Development of a micronucleus test using the EpiAirway™ organotypic human airway model
Genotoxicants | Concentration (μg/mL) | Number of BNCs observed | Number of BNCs with micronuclei | %MN | %BNCs | %BNCs (relative) | CBPI (relative) | RI (%) |
|---|---|---|---|---|---|---|---|---|
MMC | 0.00 | 1811 | 5 | 0.28 | 8.5 | 100.0 | 100.0 | 100.0 |
1.25 | 2098 | 44 | 2.10 | 7.5 | 87.7 | 99.0 | 87.7 | |
2.50 | 2125 | 88 | 4.14 | 6.2 | 72.7 | 97.9 | 72.7 | |
5.00 | 1827 | 176 | 9.63 | 6.8 | 79.4 | 98.4 | 79.4 | |
10.00 | 1033 | 171 | 16.55 | 3.7 | 43.4 | 95.6 | 43.4 | |
20.00 | 217 | 23 | 10.60 | 1.2 | 13.6 | 93.2 | 13.6 | |
MMS | 0.00 | 2001 | 2 | 0.10 | 6.9 | 100.0 | 100.0 | 100.0 |
1280.00 | 2001 | 7 | 0.35 | 7.0 | 101.7 | 100.1 | 101.7 | |
1600.00 | 2001 | 4 | 0.20 | 6.2 | 90.6 | 99.5 | 91.9 | |
2000.00 | 2001 | 12 | 0.60 | 6.0 | 87.2 | 99.2 | 87.2 | |
2500.00 | 1870 | 20 | 1.07 | 4.4 | 63.8 | 97.9 | 66.9 | |
COL | 0.00 | 2001 | 2 | 0.10 | 6.9 | 100.0 | 100.0 | 100.0 |
0.51 | 1975 | 7 | 0.35 | 5.9 | 85.7 | 99.1 | 85.7 | |
0.64 | 2001 | 9 | 0.45 | 5.7 | 82.7 | 98.9 | 82.7 | |
0.80 | 2001 | 13 | 0.65 | 4.0 | 57.9 | 97.3 | 57.9 | |
1.00 | 1555 | 32 | 2.06 | 3.8 | 55.5 | 97.5 | 60.8 | |
1.25 | 593 | 18 | 3.04 | 2.8 | 40.1 | 96.6 | 46.9 |