Table 1 Mutant frequencies in the livers of MutaMouse given styrene [Male mice were dosed once daily for 28Â days (Oral administration, tissues were collected 3Â days after the final administration)]
From: In vivo mutagenicity assessment of styrene in MutaMouse liver and lung
Substance | Dose (mg/kg/day, p.o.) | Animal ID No | Number of plaque | Number of packaging | Number of mutants | Mutant frequency (× 10−6) | Group Mean ± S.D. (× 10−6) |
|---|---|---|---|---|---|---|---|
Corn oil | 0 | 3001 | 310,500 | 1 | 13 | 41.9 | 34.1 ± 9.4 |
3002 | 306,900 | 1 | 8 | 26.1 | |||
3003 | 540,900 | 1 | 12 | 22.2 | |||
3004 | 585,900 | 1 | 25 | 42.7 | |||
3005 | 587,700 | 1 | 22 | 37.4 | |||
Styrene | 75 | 3101 | 414,000 | 1 | 13 | 31.4 | 98.5 ± 152.7 (36.3 ± 10.3) # |
3102 | 847,800 | 1 | 31 | 36.6 | |||
3103 | 798,300 | 1 | 327 | 409.6 | |||
3104 | 712,800 | 1 | 32 | 44.9 | |||
3105 | 598,500 | 1 | 13 | 21.7 | |||
3106 | 956,700 | 2 | 45 | 47.0 | |||
150 | 3201 | 662,400 | 1 | 41 | 61.9 | 48.7 ± 25.9 | |
3202 | 398,700 | 1 | 15 | 37.6 | |||
3203 | 386,100 | 1 | 10 | 25.9 | |||
3204 | 361,800 | 1 | 11 | 30.4 | |||
3205 | 546,300 | 1 | 48 | 87.9 | |||
300 | 3301 | 538,200 | 1 | 28 | 52.0 | 49.0 ± 11.1 | |
3302 | 602,100 | 1 | 27 | 44.8 | |||
3303 | 538,200 | 1 | 20 | 37.2 | |||
3304 | 736,200 | 1 | 49 | 66.6 | |||
3305 | 450,900 | 1 | 20 | 44.4 | |||
ENU | 100 | 3401 | 489,600 | 1 | 58 | 118.5 | 109.1 ± 17.1 * |
3402 | 666,000 | 1 | 62 | 93.1 | |||
3403 | 699,300 | 1 | 91 | 130.1 | |||
3404 | 666,000 | 1 | 60 | 90.1 | |||
3405 | 678,600 | 1 | 77 | 113.5 |