Table 5 DNA adducts in colon of male and female C57BL/6 mice
Experiment | DSS(%) | Days after the last DSS treatment | Male or female | Number of mice | Number of DNA adducts per 108 bases | |||
|---|---|---|---|---|---|---|---|---|
8-oxo-dG | εdA | 8-OH-AdG | HεdC | |||||
Experiment 1–1 | 0% | ー | Male | 4 | 93 ± 14 (4/4) | 1.0 ± 0.1 (3/4) | 1.0 ± 0.1 (4/4) | 2.1 ± 0.6 (4/4) |
1cycle, 1.5% | 3 days | Male | 4 | 86 ± 23 (4/4) | 1.0 ± 0.1 (3/4) | 1.1 ± 0.1 (4/4) | 1.3 ± 0.1 (3/4) | |
1cycle, 2% | 3 days | Male | 4 | 93 ± 38 (4/4) | 1.1 ± 0.4 (4/4) | 1.2 ± 0.2 (4/4) | 1.7 ± 0.5 (2/4) | |
1cycle, 2.5% | 3 days | Male | 4 | 89 ± 21 (4/4) | 1.6 ± 1.1 (3/4) | 1.2 ± 0.1 (4/4) | 1.3 ± 0.3 (2/4) | |
0% | ー | Female | 4 | 106 ± 5 (4/4) | 0.8 ± 0.2 (2/4) | 1.2 ± 0.1 (4/4) | 1.9 ± 0.2 (4/4) | |
1cycle, 1.5% | 3 days | Female | 4 | 87 ± 22 (4/4) | 0.7 ± 0.3 (4/4) | 1.1 ± 0.1 (4/4) | 1.4 ± 0.5 (4/4) | |
1cycle, 2% | 3 days | Female | 4 | 99 ± 22 (4/4) | 1.1 ± 0.3 (3/4) | 1.1 ± 0.1 (4/4) | 1.4 ± 0.2 (4/4) | |
1cycle, 2.5% | 3 days | Female | 4 | 81 ± 10 (4/4) | 0.9 ± 0.4 (3/4) | 1.2 ± 0.1 (4/4) | 1.5 ± 0.5 (4/4) | |
Experiment 1–2 | 0% | ー | Male | 2 | 126 ± 42 (2/2) | ND | 1.3 ± 0.1 (2/2) | 2.3 ± 0.5 (2/2) |
2cycle, 2% | 2 days | Male | 4 | 87 ± 15 (4/4) | 0.8 ± 0.0 (2/4) | 1.3 ± 0.3 (4/4) | 1.4 ± NA (1/4) | |
0% | ー | Female | 2 | 107 ± 22 (2/2) | ND | 1.1 ± 0.2 (2/2) | 1.6 ± 0.2 (2/2) | |
2cycle, 2.5% → 2% | 2 days | Female | 3 | 97 ± 28 (3/3) | 1.4 ± 0.8 (3/3) | 1.2 ± 0.2 (3/3) | 2.2 ± 1.4 (3/3) | |