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Fig. 3 | Genes and Environment

Fig. 3

From: Polymorphism in autophagy-related genes LRP1 and CAPZA1 may promote gastric mucosal atrophy

Fig. 3

Putative effects of LRP1 and CAPZA1 polymorphism on host defenses against CagA protein in gastric epithelial cells. The C/C or C/T genotype of rs1800137 in LRP1 or T/A or A/A genotype of rs58618380 in CAPZA1 may decrease LAMP1 expression, reduce autophagy, and accelerate CagA-mediated inflammation. Abbreviations: LAMP1, lysosome-associated membrane protein 1; CAPZA1, capping actin protein of muscle Z-line alpha subunit 1; CagA, cytotoxin-associated gene A; LRP1, low-density lipoprotein receptor-related protein 1; LRP1-ICD, LRP1 intracellular domain; IL-1β, interleukin 1 beta; IL-18, interleukin 18; TNFα, tumor necrosis factor-alpha

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