From: Polymorphism in autophagy-related genes LRP1 and CAPZA1 may promote gastric mucosal atrophy
Gene | SNP | Genotype | GMA | non-GMA | Genetic model | OR(95% CI) | P value* |
---|---|---|---|---|---|---|---|
n = 94 | n = 106 | ||||||
LRP1 | rs1799986 | G/G | 68 (72.3) | 77 (72.6) | Allele model | 1.107 (0.637–1.924) | 0.720 |
G/A | 23 (24.5) | 28 (26.4) | Dominant model | 1.015 (0.545–1.891) | 0.962 | ||
A/A | 3 (3.2) | 1 (0.9) | Recessive model | 3.462 (0.354–33.861) | 0.257 | ||
rs1800137 | C/C | 62 (66.0) | 67 (63.2) | Allele model | 0.715 (0.439–1.166) | 0.178 | |
C/T | 30 (31.9) | 28 (26.4) | Dominant model | 0.887 (0.496–1.586) | 0.685 | ||
T/T | 2 (2.1) | 11 (10.4) | Recessive model | 0.188 (0.041–0.870) | 0.018 | ||
rs1800159 | G/G | 28 (29.8) | 34 (32.1) | Allele model | 0.995 (0.670–1.476) | 0.979 | |
G/A | 48 (51.1) | 49 (46.2) | Dominant model | 1.113 (0.610–2.031) | 0.727 | ||
A/A | 18 (19.1) | 23 (21.7) | Recessive model | 0.855 (0.428–1.706) | 0.656 | ||
rs11172113 | T/T | 55 (58.5) | 73 (68.9) | Allele model | 1.129 (0.696–1.831) | 0.623 | |
T/C | 37 (39.4) | 24 (22.6) | Dominant model | 1.569 (0.878–2.804) | 0.128 | ||
C/C | 2 (2.1) | 9 (8.5) | Recessive model | 0.234 (0.049–1.113) | 0.049 | ||
rs11837145 | C/C | 26 (27.7) | 43 (40.6) | Allele model | 1.138 (0.766–1.692) | 0.523 | |
C/A | 52 (55.3) | 38 (35.8) | Dominant model | 1.785 (0.984–3.238) | 0.055 | ||
A/A | 16 (17.0) | 25 (23.6) | Recessive model | 0.665 (0.330–1.339) | 0.251 | ||
CAPZA1 | rs4423118 | G/G | 36 (38.3) | 57 (53.8) | Allele model | 1.341 (0.884–2.035) | 0.168 |
G/A | 47 (50.0) | 34 (32.1) | Dominant model | 1.874 (1.066–3.296) | 0.029 | ||
A/A | 11 (11.7) | 15 (14.2) | Recessive model | 0.804 (0.350–1.849) | 0.607 | ||
rs4525162 | C/C | 30 (31.9) | 34 (32.1) | Allele model | 0.947 (0.639–1.403) | 0.785 | |
C/T | 41 (43.6) | 43 (40.6) | Dominant model | 1.007 (0.556–1.827) | 0.981 | ||
T/T | 23 (24.5) | 29 (27.4) | Recessive model | 0.860 (0.456–1.623) | 0.642 | ||
rs10885188 | C/C | 24 (25.5) | 33 (31.1) | Allele model | 1.021 (0.689–1.514) | 0.917 | |
C/A | 53 (56.4) | 49 (46.2) | Dominant model | 1.319 (0.710–2.450) | 0.381 | ||
A/A | 17 (18.1) | 24 (22.6) | Recessive model | 0.754 (0.377–1.511) | 0.426 | ||
rs58618380 | T/T | 35 (37.2) | 56 (52.8) | Allele model | 1.254 (0.827-1.900) | 0.287 | |
T/A | 50 (53.2) | 34 (32.1) | Dominant model | 1.888 (1.072–3.325) | 0.027 | ||
A/A | 9 (9.6) | 16 (15.1) | Recessive model | 0.596 (0.250–1.420) | 0.239 | ||
rs71481135 | T/T | 67 (71.3) | 74 (69.8) | Allele model | 0.928 (0.546–1.577) | 0.783 | |
T/C | 24 (25.5) | 28 (26.4) | Dominant model | 0.932 (0.507–1.714) | 0.821 | ||
C/C | 3 (3.2) | 4 (3.8) | Recessive model | 1.000 (0.183–3.857) | 0.823 | ||
LAMP1 | rs9577230 | T/T | 74 (78.7) | 73 (68.9) | Allele model | 0.659 (0.376–1.157) | 0.145 |
T/C | 17 (18.1) | 29 (27.4) | Dominant model | 0.598 (0.314–1.137) | 0.115 | ||
C/C | 3 (3.2) | 4 (3.8) | Recessive model | 0.841 (0.183–3.857) | 1.000 | ||
rs12871648 | A/A | 41 (43.6) | 39 (36.8) | Allele model | 0.971 (0.645–1.462) | 0.887 | |
A/C | 39 (41.5) | 57 (53.8) | Dominant model | 0.753 (0.427–1.327) | 0.326 | ||
C/C | 14 (14.9) | 10 (9.4) | Recessive model | 1.680 (0.708–3.986) | 0.236 |