Table 7 The sensitivity, specificity, positive predictive value, and negative predictive value of the C/C or C/T genotype of rs1800137 in LRP1 and/or the T/A or A/A genotype of rs58618380 in CAPZA1 as a biomarker of GMA progression
From: Polymorphism in autophagy-related genes LRP1 and CAPZA1 may promote gastric mucosal atrophy
Biomarker | LRP1 | Â | CAPZA1 | Â | Statistical results | Â | Genetic diagnosis | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
rs1800137 | Â | rs58618380 | Â | OR (95% CI) | P value* | Â | sensitivity | specificity | PPV | NPV | |
Biomarker 1 | C/C or C/T |  | - |  | 5.326 (1.149–24.70) | 0.021 |  | 97.9 | 10.4 | 49.2 | 84.6 |
Biomarker 2 | - |  | T/A or A/A |  | 1.888 (1.030–1.923) | 0.033 |  | 62.8 | 52.8 | 54.1 | 61.5 |
Biomarker 3 | C/C or C/T |  | T/A or A/A |  | 2.270 (1.287–4.005) | 0.005 |  | 61.7 | 58.5 | 56.9 | 63.3 |