New insights on CRISPR/Cas9-based therapy for breast Cancer

Genes and Environment

Table 2 CRISPR/Cas9- based cancer mouse models (reviewed in [40])

Cancer type	Mouse strain	Vector	Target gene(s)	Reference
Lung adenocarcinoma	Kras^lsl-G12D/+	Lentivirus	NKX, PTEN, APC	[41]
Lung adenocarcinoma	CD1	Adenovirus	EML4	[42]
Burkitt lymphoma	Arf/− EμMyc	Retrovirus	p53	[43]
Glioblastoma	Crl:CD1 mice	Transfection	TRP53, PTEN, NF1	[10]
Acute myeloid leukemia	C57Bl/6 mice	Lentivirus	DNMT3A, EZH2, RUNX1	[1]
Burkitt lymphoma	Eμ--Myc mice	Lentivirus	p53	[44]
Pancreatic adenocarcinoma	KrasLSL-G12D/+	Lentivirus	LKB1	[45]
Lung metastases	Kras^G12D/+; p53^−/−	Lentiviral	Multiple hits	[46]
Tumor regression	Foxn1^numice	Transfection	PKCβ A509T	[47]

ISSN: 1880-7062