Fig. 2
From: Environmental impact on carcinogenesis under BRCA1 haploinsufficiency
Current understanding of iron metabolism. Recently, many novel concepts have been established regarding iron metabolism, including ferritinophagy to take out iron from ferritin, cytosolic iron chaperones, PCBP1/2 and Fe(III)-loaded ferritin release via CD63-regulated exosomes. CPN, ceruloplasmin; Dcytb, duodenal cytochrome B; DMT1, divalent metal transporter-1 (SLC11A2); FPN, ferroportin (SLC40A1); TF, transferrin; STEAP3, six-transmembrane epithelial antigen of the prostate; TfR1, transferrin receptor-1; PCBP, poly(rC) binding protein; IRE-IRP, iron-responsive element-iron regulatory protein; brown circle as Fe(II); blue circle as Fe(III); green letter, reductase; pink letter, oxidase