Environmental impact on carcinogenesis under BRCA1 haploinsufficiency

Genes and Environment

Table 1 Species differences in ferric nitrilotriacetate (Fe-NTA)-induced renal cell carcinoma in rodents

Species	Rattus norvegicus	Mus musculus
First report	1982 [82]	1987 [14]
High susceptibility in males	Yes	Yes
Cancer incidence	high (72–92%) [13, 83]	low (7–62%) [84]
Strains used	Wistar, BN, F-344, SD	A/J, C57/BL6
Strain difference	None	Prominent [84]
Pulmonary metastasis	Common (~ 50%)	Very rare
Peritoneal invasion	Common	Rare
Histology	Renal cell carcinoma	Renal cell carcinoma
Tolerable Fe-NTA dose(ip)	~ 10 mg Fe/kg/day	3 ~ 7 mg Fe/kg/day
Genetic alterations by aCGH	Marked[11]	Less marked [84, 85]
p16^Ink4a deletion	Common [11, 86]	Rare [84, 85]

ISSN: 1880-7062