Polymorphism in autophagy-related genes LRP1 and CAPZA1 may promote gastric mucosal atrophy

Genes and Environment

Table 6 Frequencies of genotypes of tag SNPs in the EGMA and non-EGMA goups

SNP ID	Genotype	EGMA	non-EGMA	Genetic model	OR(95%CI)	P value
SNP ID	Genotype	n = 123	n = 72	Genetic model	OR(95%CI)	P value
rs1800137	C/C	83	44	Allele model	1.489	0.115
	C/C	(67.5)	(61.1)	Allele model	(0.906–2.447)	0.115
	C/T	35	20	Dominant model	1.321	0.368
	C/T	(28.5)	(27.8)	Dominant model	(0.721–2.420)	0.368
	T/T	5	8	Recessive model	2.950	0.057
	T/T	(4.1)	(11.1)	Recessive model	(0.927–9.392)	0.057
rs58618380	T/T	59	30	Allele model	1.382	0.141
	T/T	(48.0)	(41.7)	Allele model	(0.898–2.123)	0.141
	T/A	52	29	Dominant model	1.291	0.368
	T/A	(42.3)	(40.3)	Dominant model	(0.718–2.322)	0.368
	A/A	12	13	Recessive model	2.038	0.094
	A/A	(9.8)	(18.1)	Recessive model	(0.875–4.749)	0.094

Genotype distribution and three genetic models, odds ratio, and p-value for each tag SNPs between the EGMA and non-EGMA groups are shown.
*Alleles and genotypes in the three genetic models were compared using chi-squared or Fisher’s exact tests (OR, odds ratio; CI, confidence interval).

ISSN: 1880-7062