Animal/species | Doses | TD50 mg/kg/day | malignancy-observed tissues | References |
---|---|---|---|---|
Rat, SD | 0.2%, in food 46 weeks |  | breast cancer adenocarcinoma | Cohen et al. [30] |
Rat, Wistar | 0.4%, in food, 18 months | 74.7 | mammary, tumor forestomach, papillomas | Takayama and Kuwabara [46] |
Rat, Wistar | Â | Â | mammary tumors | Takayama and Kuwabara [32] |
Mouse, CDF1 | 0.08/0.4%, in food 18 months | 714 | forestomach, tumors | Takayama and Kuwabara [32] |
Mouse, ICR/JCL | 0.08/0.4%, in food 440 days | 95.0 | forestomach, carcinoma/ papillomas | Yokoro et al. [47] |
Mouse, ddY | 2500 mg/kg, in food 308 days | 72.9 | forestomach, carcinoma/ papillomas | Sano et al. [31] |
Mouse, ddY | 0.05/0.15/0.45%, in food, 18 months | 550* | forestomach, carcinoma | Ochiai et al. [19] |