Fig. 2
From: Metformin suppresses proliferation and glycolysis of gastric cancer by modulating ADAMTS12
ADAMTS12 enhances GC cell proliferation and glycolysis. A: Transfection efficiency as detected by qRT-PCR; B: Cell viability after transfection as assayed by CCK-8; C: Cell proliferation after transfection as assessed via colony formation assay; D: GSEA pathway enrichment analysis reveals marked correlations of high ADAMTS12 expression with Glycolysis/Gluconeogenesis pathway; E-L: Seahorse XP 96 analysis of ECAR and OCR of GC cells in different treatment groups; M: Detection of pyruvic acid, lactate, citrate, and malate levels in GC cells in each treatment group; N-O: HK-2, ATP5D and ATP5E expression after cell transfection as tested via western blot; * P < 0.05