Lack of in vivo mutagenicity of carbendazim in the liver and glandular stomach of MutaMice

Genes and Environment

Table 2 Mutant frequencies in the glandular stomach of MutaMice treated with carbendazim

Substance	Dose (mg/kg/day)	Animal ID	No. of total plaques	No. of mutants	Mutant frequency (×10^− 6)	Mean ± S.D. (×10^− 6)
Corn oil	0	3001	608,400	16	26.3
		3002	561,600	21	37.4
		3003	354,600	19	53.6	40.6 ± 10.4
		3004	360,900	14	38.8
		3005	318,600	15	47.1
Carbendazim	250	3101	330,300	10	30.3
		3102	722,700	35	48.4
		3103	539,100	23	42.7	38.9 ± 10.5
		3104	474,300	12	25.3
		3105	333,900	16	47.9
	500	3201	360,900	16	44.3
		3202	311,400	18	57.8
		3203	593,100	26	43.8	41.1 ± 11.9
		3204	827,100	23	27.8
		3205	538,200	17	31.6
	1,000	3301	344,700	11	31.9
		3302	727,200	33	45.4
		3303	330,300	12	36.3	37.7 ± 7.2
		3304	399,600	18	45.0
		3305	398,700	12	30.1
ENU	100	3401	358,200	129	360.1
		3402	661,500	241	364.3
		3403	311,400	122	391.8	396.1 ± 53.8*(AW)
		3404	582,300	218	374.4
		3405	432,900	212	489.7

Corn oil: Negative control (10 mL/kg)
ENU: Positive control (N -ethyl-N -nitrosourea, 10 mL/kg, i.p., dose once daily for 2 days, expression period; 10 days)
*: Significant difference from negative control (p < 0.05)
(AW): Aspin-Welch’s t test

ISSN: 1880-7062