Fig. 4

Spectrum of TP53 mutations in Rwandan and non-Rwandan patients with gastric cancer. The data of Rwandan patients is from the present study (n = 29), while that of non-Rwandan patients is from the study by Natsume et al. (n = 272) [33], TCGA dataset (n = 226) [52], and the study by Wang et al. (n = 58) [43]. The pie chart illustrates the TP53 mutation spectrum categorized into six types of single nucleotide substitutions as well as non-substitution mutations. The G:C > A:T transitions were subdivided into G:C > A:T at CpG sites and non-CpG sites. Each spectrum is shown in the pie graphs as follows: A:T > C:G (blue), A:T > G:C (orange), A:T > T:A (silver), G:C > A:T at CpG (yellow), G:C > A:T at non-CpG (light blue), G:C > C:G (green), G:C > T:A (dark blue), deletion (brown), deletion-insertion (grey), insertion (golden yellow), and fusion (red)