Table 2 List of TP53 mutations identified in Rwandan gastric cancer patients
From: The spectrum of TP53 mutations in Rwandan patients with gastric cancer
Sample ID | Exon /intron | Genomic description | Coding DNA description | Protein Description | Effect | dbSNP_ID |
|---|---|---|---|---|---|---|
GC090 | Exon 4 | g.7,676,060G>T | c.309C>A | p.Y103* | Nonsense | NA |
GC057 | Exon 4 | g.7,676,055C>A | c.314G>T | p.G105V | Missense | NA |
GC060 | Exon 5 | g.7,675,206del | c.406del | p.Q136Nfs*34 | Frameshift | NA |
GC028 | Exon 5 | g.7,675,185C>T | c.427G>A | p.V143M | Missense | rs587782620 |
GC021& | Exon 5 | g.7,675,139_7,675,157del | c.459_477del | p.G154Wfs*10 | Frameshift | NA |
GC067 | Exon 5 | g.7,675,142A>G | c.470T>C | p.V157A | Missense | rs1131691023 |
GC019 | Exon 5 | g.7,675,139C>A | c.473G>T | p.R158L | Missense | rs587782144 |
GC014 | Exon 5 | g.7,675,138G>A | c.474C>T | p.Arg158= | Silent | rs139200646 |
GC053 | Exon 5 | g.7,675,094A>C | c.518T>G | p.V173G | Missense | rs1057519747 |
GC028 | Exon 5 | g.7,675,088C>T | c.524G>A | p.R175H | Missense | rs28934578 |
GC080 | Exon 5 | g.7,675,088C>T | c.524G>A | p.R175H | Missense | rs28934578 |
GC042 | Exon 5 | g.7,675,085C>A | c.527G>T | p.C176F | Missense | rs786202962 |
GC071 | Exon 5 | g.7,675,085C>A | c.527G>T | p.C176F | Missense | rs786202962 |
GC079 | Exon 5 | g.7,675,085C>A | c.527G>T | p.C176F | Missense | rs786202962 |
GC028 | Exon 6 | g.7,674,954G>A | c.577C>T | p.H193Y | Missense | rs876658468 |
GC075 | Exon 6 | g.7,674,950A>C | c.581T>G | p.L194R | Missense | rs1057519998 |
GC084 | Exon 6 | g.7,674,945G>A | c.586C>T | p.R196* | Nonsense | rs397516435 |
GC059 | Exon 6 | g.7,674,894G>A | c.637C>T | p.R213* | Nonsense | rs397516436 |
GC060 | Exon 6 | g.7,674,894G>A | c.637C>T | p.R213* | Nonsense | rs397516436 |
GC066 | Exon 6 | g.7,674,894G>A | c.637C>T | p.R213* | Nonsense | rs397516436 |
GC006 | Exon 6 | g.7,674,893C>A | c.638G>T | p.R213L | Missense | rs587778720 |
GC051 | Exon 6 | g.7,674,885C>T | c.646G>A | p.V216M | Missense | rs730882025 |
GC081 | Exon 6 | g.7,674,877del | c.654del | p.Y220Mfs*27 | Frameshift | NA |
GC038 | Exon 7 | g.7,674,230C>T | c.733G>A | p.G245S | Missense | rs28934575 |
GC067 | Exon 7 | g.7,674,230C>T | c.733G>A | p.G245S | Missense | rs28934575 |
GC014 | Intron 7 | g.7,674,180C>T | c.782+1G>A | p.? | Splice-site | NA |
GC035 | Exon 8 | g.7,673,776G>C | c.844C>G | p.R282G | Missense | rs28934574 |
GC106 | Exon 8 | g.7,673,776G>A | c.844C>T | p.R282W | Missense | rs28934574 |
GC089 | Exon 8 | g.7,673,763T>A | c.857A>T | p.E286V | Missense | rs1057519985 |