Table 3 Relationship between the clinicopathological characteristics and TP53 mutation status in Rwandan patients with gastric cancer (n = 95)
From: The spectrum of TP53 mutations in Rwandan patients with gastric cancer
Characteristics | Number of cases (percentage) | p value | |
|---|---|---|---|
|  | TP53 mutant (n = 24) | TP53 wild-type (n = 71) |  |
Age (y.o.) | Â | Â | 0.276 |
Mean ± standard deviation | (63.3 ± 11.1) | (59.7 ± 14.5) |  |
Range | (40–80) | (29–99) |  |
Age group | Â | Â | 0.190 |
< 45 | 2 (8.3) | 13 (18.3) |  |
45–54 | 5 (20.8) | 11 (15.5) |  |
55–64 | 3 (12.5) | 20 (28.2) |  |
65–74 | 10 (41.7) | 15 (21.1) |  |
75- | 4 (16.7) | 12 (16.9) | Â |
Sex | Â | Â | 0.956 |
Female | 13 (54.2) | 38 (53.5) | Â |
Male | 11 (45.8) | 33 (46.5) | Â |
Anatomic site of the tumor | Â | Â | 0.620 |
Cardia | 1 (4.2) | 7 (9.9) | Â |
Sub-cardia | 0 (0.0) | 3 (4.2) | Â |
Fundus | 3 (12.5) | 9 (12.7) | Â |
Corpus | 0 (0.0) | 3 (4.2) | Â |
Corpus-antrum | 0 (0.0) | 2 (2.8) | Â |
Antrum | 15 (62.5) | 39 (54.9) | Â |
Antro-pyloric | 1 (4.2) | 3 (4.2) | Â |
Pyloric | 4 (16.7) | 5 (7.0) | Â |
Laurén’s classification |  |  | 0.793 |
Intestinal | 7 (29.2) | 15 (21.1) | Â |
Indeterminate | 2 (8.3) | 4 (5.6) | Â |
Diffuse | 4 (16.7) | 20 (28.2) | Â |
Mixed | 9 (37.5) | 27 (38) | Â |
Not defined | 2 (8.3) | 5 (7.0) | Â |
WHO classification | Â | Â | 0.427 |
Papillary | 0 (0) | 5 (7.0) | Â |
Tubular, well-differentiated | 0 (0) | 1 (1.4) | Â |
Tubular, moderately differentiated | 7 (29.2) | 9 (12.7) | Â |
Tubular, poorly differentiated | 2 (8.3) | 4 (5.6) | Â |
Poorly cohesive, signet-ring cell phenotype | 2 (8.3) | 5 (7.0) | Â |
Poorly cohesive, other cell types | 2 (8.3) | 15 (21.1) | Â |
Mixed | 9 (37.5) | 27 (38) | Â |
Undifferentiated carcinoma | 2 (8.3) | 3 (4.2) | Â |
Neuroendocrine carcinoma | 0 (0) | 2 (2.8) | Â |