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Table 2 Socio-demographic, Parasitological and clinical characteristics of the Plasmodium falciparum infected children

From: Toll-like receptor (TLR4) Asp299Gly and Thr399Ile polymorphisms in relation to clinical falciparum malaria among Nigerian children: a multisite cross-sectional immunogenetic study in Lagos

Parameter

Study participants

P

Total

Clinical malaria

Asymptomatic malaria

(n = 279)

(n = 182)

(n = 97)

 

Age, median (Range), months

52 (8 – 110)

52 (8 – 110)

51 (10–105)

ND

Age, mean ± SEM, months

56.7 ± 1.4

57.3 ± 1.7

55.6 ± 2.5

0.59

Age group, n (%)

    

6 – 24

14 (5)

8 (4.4)

6 (6.2)

0.54

25 – 59

152 (54.5)

101 (55.5)

51 (52.6)

0.69

60 and above

113 (40.5)

73 (40.1)

40 (41.2)

0.86

Gender

    

Male, n (%)

167 (59.9)

113 (62.1)

54 (55.7)

0.29

Geometric mean parasite density (95 % CI), parasites/uL

5470 (2,170 – 7,770)

10,200 (5,300 – 15,100)

1,690 (1340 – 2040)

<0.001

Hyperparasitaemia

    

(parasitaemia > 250,000/uL), n (%) High parasite density

2 (0.7)

2 (1.1)

0 (0)

ND

(parasitaemia >10,000/uL), n (%)

62 (22.2)

62 (33.2)

0 (0)

ND

Axillary body temperature, mean ± SEM, °C

37.1 ± 0.04

37.2 ± 0.05

36.8 ± 0.03

<0.0001

Hyperpyrexia (> 40 °C), n (%)

5 (1.8)

5 (2.7)

0 (0)

ND

Hb, mean ± SEM (range), g/dl

11.6 ± 0.1 (4.2 – 14.1)

11.3 ± 0.2 (4.2 – 13.4)

12.2 ± 0.1 (10.2 – 14.1)

<0.001

Anaemia (Hb < 11 g/dl), n (%)

49 (17.6)

37 (20.3)

12 (12.4)

ND

Severe anaemia, (Hb < 6 g/dl), n (%)

15 (5.4)

15 (8.2)

0 (0)

 

Indices of malnutrition, n (%)

    

WAZ (n = 224)

  

14 (16.9)

 

< −2 SD

50 (22.3)

36 (25.5)

68 (81.9)

 

−2 – to 2 SD

171 (76.3)

103 (73.0)

1 (1.2)

0.14

>2 SD

3 (1.4)

2 (1.5)

  

HAZ (n = 239)

  

11 (13.3)

 

< −2 SD

57 (23.8)

46 (29.5)

70 (84.3)

0.006

−2 – to 2 SD

176 (73.6)

106 (67.9)

2 (2.4)

 

>2 SD

6 (2.6)

4 (2.6)

1 (1.2)

 

WHZ (n = 215)

    

< −2 SD

8 (3.7)

7 (5.3)

79 (96.3)

0.001

−2 – to 2 SD

204 (94.9)

125 (94.0)

2 (2.5)

 

>2 SD

3 (1.4)

1 (0.7)

  
  1. ND = Not determined. Differences in malnutrition indices: weight for age WAZ), height for age (HAZ) and weight for height (WHZ) z scores between clinical and asymptomatic malarial children was evaluated with a 2 by 3 contingency table using chi-square (χ2) test. Disparity in mean values was evaluated using Student’s t-test. P < 0.05 was considered to be significant