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  1. Helicobacter pylori secretes cytotoxin-associated gene A (CagA) into the gastric epithelium, causing gastric mucosal atrophy (GMA) and gastric cancer. In contrast, host cells degrade CagA via autophagy. However, ...

    Authors: Naoyuki Yamaguchi, Takuki Sakaguchi, Hajime Isomoto, Tatsuo Inamine, Ryoya Tsukamoto, Daisuke Fukuda, Ken Ohnita, Tsutomu Kanda, Kayoko Matsushima, Tatsuro Hirayama, Kazuo Yashima and Kazuhiro Tsukamoto
    Citation: Genes and Environment 2023 45:18
    Content type: Research Published on:

  2. Environmental heat stress in dairy cattle leads to poor health, reduced milk production and decreased reproductive efficiency. Multiple genes interact and coordinate the response to overcome the impact of heat...

    Authors: Basavaraj Sajjanar, Mohd Tanzeel Aalam, Owais Khan, Gunturu Narasimha Tanuj, Aditya Prasad Sahoo, Gundallahalli B. Manjunathareddy, Ravi Kumar Gandham, Sujoy K. Dhara, Praveen K. Gupta, Bishnu Prasad Mishra, Triveni Dutt and Gyanendra Singh
    Citation: Genes and Environment 2023 45:17
    Content type: Research Published on:

  3. The human population living in high level natural radiation areas (HLNRAs) of Kerala coast provide unique opportunities to study the biological effects of low dose and low dose rate ionizing radiation below 10...

    Authors: Vinay Jain, Divyalakshmi Saini, D. C. Soren, V. Anil Kumar, P. R. Vivek Kumar, P. K. M. Koya, G. Jaikrishan and Birajalaxmi Das
    Citation: Genes and Environment 2023 45:16
    Content type: Research Published on:

  4. Chronic inflammation induces DNA damage and promotes cell proliferation, thereby increasing the risk of cancer. DNA polymerase κ (Pol κ), involved in translesion DNA synthesis, counteracts mutagenesis induced ...

    Authors: Atsushi Hakura, Hajime Sui, Yuki Seki, Jiro Sonoda, Yusaku Yoshida, Hisayoshi Takagi, Shigeo Yokose, Tomonari Matsuda, Shoji Asakura and Takehiko Nohmi
    Citation: Genes and Environment 2023 45:15
    Content type: Research Published on:

  5. The use of organotypic human tissue models in genotoxicity has increased as an alternative to animal testing. Genotoxicity is generally examined using a battery of in vitro assays such as Ames and micronucleus...

    Authors: Satoru Munakata, Taku Watanabe, Tomohiro Takahashi, Shiori Kimuro, Kanae Ishimori and Tsuneo Hashizume
    Citation: Genes and Environment 2023 45:14
    Content type: Research Published on:

  6. DNA oxidatively damaged by reactive oxygen species is repaired by base excision repair (BER) pathway proteins, with DNA glycosylases removing damaged or mismatched bases in the first step of BER. KsgA is a mul...

    Authors: Yuichiro Hayashi, Masafumi Funakoshi, Kaname Hirosawa and Qiu-Mei Zhang-Akiyama
    Citation: Genes and Environment 2023 45:13
    Content type: Research Published on:

  7. Styrene (CAS 100-42-5) is widely used as polystyrene and acrylonitrile–butadiene–styrene resin such as plastic, rubber, and paint. One of the primary uses of styrene is food utensils and containers, but a smal...

    Authors: Yasumasa Murata, Masakatsu Natsume, Takako Iso, Yoshiyuki Shigeta, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Kenichi Masumura, Akihiko Hirose and Mariko Matsumoto
    Citation: Genes and Environment 2023 45:12
    Content type: Research Published on:

  8. Apoptotic cell death is an important survival system for multicellular organisms because it removes damaged cells. Mutation is also a survival method for dealing with damaged cells in multicellular and also un...

    Authors: Megumi Toyoshima-Sasatani, Fumika Imura, Yuko Hamatake, Akihiro Fukunaga and Tomoe Negishi
    Citation: Genes and Environment 2023 45:11
    Content type: Research Published on:

  9. Exposure to certain chemicals in the environment may contribute to the risk of developing cancer. Although cancer risk from environmental chemical exposure among general populations is considered low compared ...

    Authors: Motoki Iwasaki, Hiroaki Itoh, Norie Sawada and Shoichiro Tsugane
    Citation: Genes and Environment 2023 45:10
    Content type: Review Published on:

  10. The Open Symposium of the Japanese Environmental Mutagen and Genome Society (JEMS) entitled “Analytical technologies to revolutionize the environmental mutagenesis and genome research -From the basics to the c...

    Authors: Naoki Koyama and Akira Sassa
    Citation: Genes and Environment 2023 45:9
    Content type: Meeting report Published on:

  11. Colibactin is a genotoxin produced by Escherichia coli and other Enterobacteriaceae that is believed to increase the risk of colorectal cancer (CRC) of their symbiosis hosts, including human. A peptidase ClbP is ...

    Authors: Tao Zhou, Takayuki Ando, Akihiro Kudo, Michio Sato, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Keiji Wakabayashi and Kenji Watanabe
    Citation: Genes and Environment 2023 45:8
    Content type: Research Published on:

  12. Next-generation RNA sequencing (RNA-Seq) has identified more differentially expressed protein-coding genes (DEGs) and provided a wider quantitative range of expression level changes than conventional DNA micro...

    Authors: Chie Furihata and Takayoshi Suzuki
    Citation: Genes and Environment 2023 45:7
    Content type: Review Published on:

  14. Heat shock proteins (Hsps) are overexpressed in several tumors and contribute to cell proliferation, metastasis, and anticancer drug resistance. Therefore, Hsp inhibitors have enhanced cytotoxicity as chemothe...

    Authors: Takahiro Matsumoto, Erika Ohnishi, Takahiro Kitagawa, Masaya Okayama, Youhei Saito, Hayato Yoshikawa, Tomoe Ohta, Tatsusada Yoshida, Yuji Nakayama and Tetsushi Watanabe
    Citation: Genes and Environment 2023 45:5
    Content type: Research Published on:

  15. Genotoxicity in tissues other than hematopoietic tissues, such as the liver and gastrointestinal (GI) tract, is an important focus in the risk assessment of chemicals in humans. We previously developed a rat m...

    Authors: Wakako Ohyama, Yohei Fujiishi, Emiko Okada, Kazunori Narumi and Makoto Hayashi
    Citation: Genes and Environment 2023 45:4
    Content type: Research Published on:

  16. Non-thermal atmospheric pressure plasma technologies form the core of many scientific advances, including in the electronic, industrial, and biotechnological fields. The use of plasma as a cancer therapy has r...

    Authors: Yang Liu, Yoshimichi Nakatsu, Hiromasa Tanaka, Kazunori Koga, Kenji Ishikawa, Masaharu Shiratani and Masaru Hori
    Citation: Genes and Environment 2023 45:3
    Content type: Research Published on:

  17. Cancer is the primary cause of human mortality in Japan since 1981. Although numerous novel therapies have been developed and applied in clinics, the number of deaths from cancer is still increasing worldwide....

    Authors: Shinya Toyokuni, Yingyi Kong, Yashiro Motooka and Shinya Akatsuka
    Citation: Genes and Environment 2023 45:2
    Content type: Review Published on:

  18. Mutation spectrum of TP53 in gastric cancer (GC) has been investigated world-widely, but a comparison of mutation spectrum among GCs from various regions in the world are still sparsely documented. In order to id...

    Authors: Hiroko Natsume, Kinga Szczepaniak, Hidetaka Yamada, Yuji Iwashita, Marta Gędek, Jelena Šuto, Keiko Ishino, Rika Kasajima, Tomonari Matsuda, Felix Manirakiza, Augustin Nzitakera, Yijia Wu, Nong Xiao, Qiong He, Wenwen Guo, Zhenming Cai…
    Citation: Genes and Environment 2023 45:1
    Content type: Research Published on:

  19. Previously, we reported the inhibitory effect of Actinidia arguta juice, known as sarunashi juice (sar-j) in Japan, on mutagenesis, inflammation, and mouse skin tumorigenesis. The components of A. arguta responsi...

    Authors: Jun Takata, Naoko Miyake, Yusuke Saiki, Misako Tada, Kensuke Sasaki, Toshio Kubo, Katsuyuki Kiura and Sakae Arimoto-Kobayashi
    Citation: Genes and Environment 2022 44:26
    Content type: Research Published on:

  21. Multiwalled carbon nanotubes (MWCNTs) are suspected lung carcinogens because their shape and size are similar to asbestos. Various MWCNT types are manufactured; however, only MWNT-7 is classified into Group 2B...

    Authors: Katsuyoshi Horibata, Hironao Takasawa, Motoki Hojo, Yuhji Taquahashi, Miyuki Shigano, Satoshi Yokota, Norihiro Kobayashi, Kei-ichi Sugiyama, Masamitsu Honma and Shuichi Hamada
    Citation: Genes and Environment 2022 44:24
    Content type: Short report Published on:

  22. Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary vascular remodeling, which can be caused by abnormal proliferation and migration of pulmonary artery smooth muscle cells (PASMCs). Sev...

    Authors: Ting Li, Xiaoqin Tan, Yuexia Huang, Jun Cui, Fan Chen and Ying Xiong
    Citation: Genes and Environment 2022 44:23
    Content type: Research Published on:

  24. The repeated-dose liver micronucleus (RDLMN) assay has been well-developed and applied because of its simplicity and the ease of integration into general toxicity studies which is the preferred method from the...

    Authors: Kensuke Satomoto, Isamu Suzuki, Koji Mita, Atsushi Wakita, Hiroshi Yamagata, Tatsuya Mitsumoto and Shuichi Hamada
    Citation: Genes and Environment 2022 44:21
    Content type: Short report Published on:

  25. Bisphenol-A (BPA) is an important environmental contaminant with adverse health effects suspected to be mediated through epigenetic mechanisms. We had reported that the FLO1-dependent flocculation of transgeni...

    Authors: Kei-ichi Sugiyama, Mawo Kinoshita, Petr Grúz, Toshio Kasamatsu and Masamitsu Honma
    Citation: Genes and Environment 2022 44:20
    Content type: Research Published on:

  27. Patatin-like phospholipase domain containing 3 (PNPLA3) is the main nonalcoholic fatty liver disease (NAFLD) susceptibility. Its expression is regulated tightly by nutritional and energy status, but the mechan...

    Authors: Xiao Xu, Xiaojie Deng, Yunzhi Chen, Wen Xu, Fen Xu and Hua Liang
    Citation: Genes and Environment 2022 44:18
    Content type: Research Published on:

  28. The principal objective of this project was to investigate the Epidermal Growth Factor Receptor (EGFR) gene mutation characteristics of lung cancer patients, which can provide a molecular basis for explaining the...

    Authors: Jun-Ling Wang, Yu-Dong Fu, Yan-Hong Gao, Xiu-Ping Li, Qian Xiong, Rui Li, Bo Hou, Ruo-Shan Huang, Jun-Feng Wang, Jian-Kun Zhang, Jia-Ling Lv, Chao Zhang and Hong-Wei Li
    Citation: Genes and Environment 2022 44:17
    Content type: Research Published on:

  29. The most frequent malignancy in women is breast cancer (BC). Gastric cancer (GC) is also the leading cause of cancer-related mortality. Long non-coding RNAs (lncRNAs) are thought to be important neurotic regul...

    Authors: Mansoureh Azadeh, Ali Salehzadeh, Kamran Ghaedi and Soheila Talesh Sasani
    Citation: Genes and Environment 2022 44:16
    Content type: Research Published on:

  30. Purpurin (1,2,4-trihydroxy-9,10-anthraquinone), a natural red anthraquinone pigment, has historically been used as a textile dye. However, purpurin induced urinary bladder tumors in rats, and displayed a mutag...

    Authors: Hatasu Kobayashi, Yurie Mori, Ryo Iwasa, Yuichiro Hirao, Shinya Kato, Shosuke Kawanishi, Mariko Murata and Shinji Oikawa
    Citation: Genes and Environment 2022 44:15
    Content type: Research Published on:

  31. In eye-drop drug development, the additional genotoxicity tests in some cases might be necessary to assess genotoxicity in the ocular surface since the ocular surface is exposed directly to high drug concentra...

    Authors: Haruna Tahara, Yoshinori Yamagiwa, Yu Haranosono and Masaaki Kurata
    Citation: Genes and Environment 2022 44:14
    Content type: Research Published on:

  33. We previously developed a rodent gastrointestinal (GI) tract micronucleus (MN) test using the glandular stomach and/or colon, and evaluated this test method using several genotoxic carcinogens (clastogens) and...

    Authors: Emiko Okada, Yohei Fujiishi, Kazunori Narumi and Wakako Ohyama
    Citation: Genes and Environment 2022 44:12
    Content type: Research Published on:

  34. Several rodent models with chemically induced colon cancer have been developed. Among these models, dextran sulfate sodium (DSS), a colitis inducer, combined with azoxymethane as a colon mutagenic carcinogen, ...

    Authors: Atsushi Hakura, Naoki Koyama, Yuki Seki, Jiro Sonoda and Shoji Asakura
    Citation: Genes and Environment 2022 44:11
    Content type: Research Published on:

  35. Aromatic amines, often used as intermediates for pharmaceutical synthesis, may be mutagenic and therefore pose a challenge as metabolites or impurities in drug development. However, predicting the mutagenicity...

    Authors: Ayaka Furukawa, Satoshi Ono, Katsuya Yamada, Nao Torimoto, Mahoko Asayama and Shigeharu Muto
    Citation: Genes and Environment 2022 44:10
    Content type: Short report Published on:

  36. Environmental pollution is a risk factor for adverse birth outcomes, especially preterm birth (PTB) and early-term birth (ETB). It has been revealed that exposure to fine particulate matter (PM2.5) during pregnan...

    Authors: Kaixin Cao, Hongyan Jin, Haoxin Li, Mengmeng Tang, Jianhong Ge, Zekang Li, Xiaoyun Wang and Xuetao Wei
    Citation: Genes and Environment 2022 44:9
    Content type: Research Published on:

  37. Airborne particulate matter (PM), a complex mixture of organic and inorganic compounds, is a major public health concern due to its adverse health effects. Understanding the biological action of PM is of parti...

    Authors: Ji Yun Lee, Won Kee Lee and Dong Sun Kim
    Citation: Genes and Environment 2022 44:8
    Content type: Research Published on:

  38. Urea (Ua) is produced in DNA as the result of oxidative damage to thymine and guanine. It was previously reported that Klenow fragment (Kf) exo− incorporated dATP opposite Ua, and that DNA polymerase β was blocke...

    Authors: Taishu Kawada, Katsuhito Kino, Kyousuke Tokorodani, Ryuto Anabuki, Masayuki Morikawa, Takanobu Kobayashi, Kazuaki Ohara, Takayuki Ohshima and Hiroshi Miyazawa
    Citation: Genes and Environment 2022 44:7
    Content type: Short report Published on:

  41. Recently, it was revealed that uric acid is a photosensitizer of reactions of nucleosides on irradiation with UV light at wavelengths longer than 300 nm, and two products generated from 2′-deoxycytidine were i...

    Authors: Toshinori Suzuki, Miyu Takeuchi and Atsuko Ozawa-Tamura
    Citation: Genes and Environment 2022 44:4
    Content type: Research Published on:

  43. Currently, revisions to the ICH S1 guidance on rodent carcinogenicity testing are being proposed. Application of this approach would reduce the use of animals in accordance with the 3Rs principles (reduce/refi...

    Authors: Shuichi Hamada, Miyuki Shigano, Yumi Wako, Kazufumi Kawasako, Kensuke Satomoto, Tatsuya Mitsumoto, Takayuki Fukuda, Wakako Ohyama, Takeshi Morita and Makoto Hayashi
    Citation: Genes and Environment 2022 44:2
    Content type: Research Published on:

  44. The human population residing in monazite bearing Kerala coast are exposed to chronic low dose and low dose rate external gamma radiation due to Th232 deposits in its beach sand. The radiation level in this ar...

    Authors: K. R. Sudheer, P. K. Mohammad Koya, Anu J. Prakash, Ambily M. Prakash, R. Manoj Kumar, S. Shyni, C. K. Jagadeesan, G. Jaikrishan and Birajalaxmi Das
    Citation: Genes and Environment 2022 44:1
    Content type: Research Published on:

  45. Workers in electronics manufacturers may be exposed to various occupational hazards such as isopropanol, lead, and noise. Telomeres are special segments of cap-like DNA protein complex at end of liner chromoso...

    Authors: Yao Lu, Xinxia Liu, Zhiqiang Zhao, Xiaoyan Ou, Yarui Yang, Qing Wei, Jingli Chen, Jun Jiang, Yi Sun, Heping Zhao, Sai Wu and Yun He
    Citation: Genes and Environment 2021 43:57
    Content type: Research Published on:

  46. The microbial ecosystem in the human gut varies between individuals with differences in diet. Selenium is one of most common trace elements in everyday diet, and selenium intake affects the human gut microbiot...

    Authors: Zi-xiong Zhang, Hua Xiang, Guo-gen Sun, Yan-hua Yang, Chen Chen and Tuo Li
    Citation: Genes and Environment 2021 43:56
    Content type: Research Published on:

  47. Neurodegenerative diseases are becoming major socio-economic burdens. However, most of them still have no effective treatment. Growing evidence indicates excess exposure to pesticides are involved in the devel...

    Authors: Guangxia Yu, Qianqian Su, Yao Chen, Lingyan Wu, Siying Wu and Huangyuan Li
    Citation: Genes and Environment 2021 43:55
    Content type: Review Published on:

  48. The PIG-A gene mutation assay is a valuable tool for measuring in vivo gene mutations in blood cells. The human PIG-A assay, used as a potential genotoxicity biomarker, is minimally invasive, sensitive, and cost-...

    Authors: Yiyi Cao, Jing Xi, Chuanxi Tang, Ziying Yang, Weiying Liu, Xinyue You, Nannan Feng, Xin Yu Zhang, Jingui Wu, Yingxin Yu and Yang Luan
    Citation: Genes and Environment 2021 43:54
    Content type: Research Published on:

  49. In 2020, we discovered glycoprotein 2 (GP2) variants associated with pancreatic cancer susceptibility in a genome-wide association study involving the Japanese population. Individuals carrying a missense coding v...

    Authors: Yingsong Lin, Masahiro Nakatochi, Naoki Sasahira, Makoto Ueno, Naoto Egawa, Yasushi Adachi and Shogo Kikuchi
    Citation: Genes and Environment 2021 43:53
    Content type: Review Published on:

  50. DNA adducts, covalent modifications to DNA due to exposure to specific carcinogens, cause the mispairing of DNA bases, which ultimately results in DNA mutations. DNA methylation in the promoter region, another...

    Authors: Yuto Matsushita, Yuji Iwashita, Shunsuke Ohtsuka, Ippei Ohnishi, Takashi Yamashita, Hideaki Miyake and Haruhiko Sugimura
    Citation: Genes and Environment 2021 43:52
    Content type: Research Published on:

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