Articles

Thorium and fetal neural tube defects: an epidemiological evidence from large case-control study

Thorium is ubiquitous in the environment and its relationship with birth defects is still under discussion. This study aimed to investigate the associations of maternal exposure to thorium with risk of neural ...

Authors: Bin Wang, Yiming Pang, Yali Zhang, Le Zhang, Rongwei Ye, Lailai Yan, Zhiwen Li and Aiguo Ren

Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan

Mutation, inflammation, and oxidative damage including lipid-peroxidation are factors involved in the development of cancer. We investigated the antimutagenic, in vivo and in vitro anti-inflammatory, and antioxid...

Authors: Sakae Arimoto-Kobayashi, Ryoko Hida, Nana Fujii and Ryosuke Mochioka

Comprehensive analysis of differences of N⁶-methyladenosine of lncRNAs between atrazine-induced and normal Xenopus laevis testis

Increasing evidence suggested N⁶-methyladenosine (m⁶A) modification is crucial for male germline development. However, m⁶A modification of lncRNAs gains a little attention in amphibians in recent years. Xenopus l...

Authors: Xuejie Qi, Xiao Geng, Juan Zhang, Binpeng Qu, Xin Zhang, Qiang Jia, Wenhui Yin, Cunxiang Bo, Yan Liu, Hao Li, Linlin Sai, Mingming Han and Cheng Peng

Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis

We aimed to conduct a meta-analysis to accurately evaluate the potential association between ADIPOQ rs2241766 gene SNP and breast cancer risk.

Authors: Xue Hu, Chunguo Cui, Tong Sun and Wan Wang

The critical role of epigenetic mechanism in PM_2.5-induced cardiovascular diseases

Cardiovascular disease (CVD) has become the leading cause of death worldwide, which seriously threatens human life and health. Epidemiological studies have confirmed the occurrence and development of CVD are c...

Authors: Qinglin Sun, Xiaoke Ren, Zhiwei Sun and Junchao Duan

Recent progress and perspectives on the mechanisms underlying Asbestos toxicity

Most cases of mesothelioma are known to result from exposure to asbestos fibers in the environment or occupational ambient air. The following questions regarding asbestos toxicity remain partially unanswered: ...

Authors: Akio Kuroda

Genetic interaction between RLM1 and F-box motif encoding gene SAF1 contributes to stress response in Saccharomyces cerevisiae

Stress response is mediated by the transcription of stress-responsive genes. The F-box motif protein Saf1p is involved in SCF-E3 ligase mediated degradation of the adenine deaminase, Aah1p upon nutrient stress...

Authors: Meenu Sharma, V. Verma and Narendra K. Bairwa

Folate metabolism modifies chromosomal damage induced by 1,3-butadiene: results from a match-up study in China and in vitro experiments

To explore the role of folate metabolism in 1,3-Butadiene (BD)'s genotoxicity, we conducted a match-up study in BD-exposed workers in China to analyze the associations between the polymorphisms of methylenetet...

Authors: Menglong Xiang, Zhi Wang, Peng Zou, Xi Ling, Guowei Zhang, Ziyuan Zhou, Jia Cao and Lin Ao

Comparison of the frequencies of ENU-induced point mutations in male germ cells and inherited germline mutations in their offspring

Gene mutations induced in germ cells may be transmitted to the next generation and cause adverse effects such as genetic diseases. Certain mutations may result in infertility or death in early development. Thu...

Authors: Kenichi Masumura, Tomoko Ando, Naomi Toyoda-Hokaiwado, Akiko Ukai, Takehiko Nohmi and Masamitsu Honma

Fc receptor-like 1, 3, and 6 variants are associated with rheumatoid arthritis risk in the Chinese Han population

Rheumatoid arthritis (RA) is the most common autoimmune system diseases in our world. More studies in recent years have shown that FCRL gene polymorphisms is closely related to autoimmune diseases. It is suggeste...

Authors: Yonghui Yang, Dandan Li, Chunjuan He, Linna Peng, Shishi Xing, Mei Bai, Hao Rong, Dongya Yuan, Yongjun He, Xue He, Li Wang and Tianbo Jin

Bacterial mutagenicity test data: collection by the task force of the Japan pharmaceutical manufacturers association

Ames test is used worldwide for detecting the bacterial mutagenicity of chemicals. In silico analyses of bacterial mutagenicity have recently gained acceptance by regulatory agencies; however, current in silico m...

Authors: Atsushi Hakura, Takumi Awogi, Toshiyuki Shiragiku, Atsushi Ohigashi, Mika Yamamoto, Kayoko Kanasaki, Hiroaki Oka, Yasuaki Dewa, Shunsuke Ozawa, Kouji Sakamoto, Tatsuya Kato and Eiji Yamamura

MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Previous studies have shown the effect of MTHFR A1298C gene polymorphism on stroke risk. But the results of published studies remained inconclusive and controversial. So we conducted a meta-analysis to accurately...

Authors: Xiaobo Dong, Jun Wang, Gesheng Wang, Jiayue Wang, Lei Wang and Yong Du

Advances in neural organoid systems and their application in neurotoxicity testing of environmental chemicals

Due to the complex structure and function of central nervous system (CNS), human CNS in vitro modeling is still a great challenge. Neurotoxicity testing of environmental chemicals mainly depends on the traditi...

Authors: Yuanyuan Zheng, Fangrong Zhang, Shengmin Xu and Lijun Wu

Mutagenicity of carcinogenic heterocyclic amines in Salmonella typhimurium YG strains and transgenic rodents including gpt delta

Chemical carcinogens to humans have been usually identified by epidemiological studies on the relationships between occupational or environmental exposure to the agents and specific cancer induction. In contra...

Authors: Takehiko Nohmi and Masahiko Watanabe

The effect of aging on the repeated-dose liver micronucleus assay

The liver micronucleus (MN) assay is an effective and important in vivo test for detecting genotoxic compounds. In particular, the repeated-dose liver MN (RDLMN) assay which greatly facilitates incorporation o...

Authors: Miyuki Shigano, Hironao Takasawa and Shuichi Hamada

High resolution melting analysis and detection of Leishmania resistance: the role of multi drug resistance 1 gene

Pentavalent antimonial compounds are currently used to treat leishmaniasis and resistance to these drugs is a serious problem. Multidrug resistance protein is an efflux pump of the cell membrane that expels fo...

Authors: Maryam Fekri Soofi Abadi, Alireza Moradabadi, Reza Vahidi, Saeedeh Shojaeepour, Sara Rostami, Iman Rad and Shahriar Dabiri

PRDX1 is essential for the viability and maintenance of reactive oxygen species in chicken DT40

Peroxiredoxin 1 (PRDX1) is a member of a ubiquitous family of thiol peroxidases that catalyze the reduction of peroxides, including hydrogen peroxide. It functions as an antioxidant enzyme, similar to catalase...

Authors: Takahito Moriwaki, Akari Yoshimura, Yuki Tamari, Hiroyuki Sasanuma, Shunichi Takeda, Masayuki Seki and Keizo Tano

miR221 regulates cell migration by targeting annexin a1 expression in human mesothelial MeT-5A cells neoplastic-like transformed by multi-walled carbon nanotube

Multi-walled carbon nanotube (MWCNT) is one of the most widely used manufactured nanomaterials, however, its potential harmful effect on human health is of great concern. Previously we have shown the acute and...

Authors: Li Ju, Lijin Zhu, Hao Wu, Min Yu, Xianhong Yin, Zhenyu Jia, Lingfang Feng, Shibo Ying, Hailing Xia, Shuzhi Zhang, Jianlin Lou and Jun Yang

Dietary heterocyclic aromatic amine intake and cancer risk: epidemiological evidence from Japanese studies

Heterocyclic aromatic amines (HAAs), which are formed from the reaction of creatine or creatinine, amino acids, and sugars in meat and fish cooked at high temperatures, have been shown to be mutagenic in bacte...

Authors: Motoki Iwasaki and Shoichiro Tsugane

Gene expression analysis in NSAID-induced rat small intestinal disease model with the intervention of berberine by the liquid chip technology

Investigate the effect and mechanism of berberine on the small intestinal mucosa of non-steroidal anti-inflammatory drugs (NSAIDs) related small intestinal injury.

Authors: Guanqun Chao, Qianqian Wang, Fangxu Ye and Shuo Zhang

Achievements and memories of Dr. Takashi Sugimura

Authors: Keiji Wakabayashi

In vivo and in vitro mutagenicity of perillaldehyde and cinnamaldehyde

Perillaldehyde and cinnamaldehyde are natural substances found in plants that are used as flavoring ingredients. Due to the α,β-unsaturated aldehydes in their structures, these compounds are expected to be DNA...

Authors: Masamitsu Honma, Masami Yamada, Manabu Yasui, Katsuyoshi Horibata, Kei-ichi Sugiyama and Kenichi Masumura

Metabolism and biomarkers of heterocyclic aromatic amines in humans

Heterocyclic aromatic amines (HAAs) form during the high-temperature cooking of meats, poultry, and fish. Some HAAs also arise during the combustion of tobacco. HAAs are multisite carcinogens in rodents, induc...

Authors: Medjda Bellamri, Scott J. Walmsley and Robert J. Turesky

Free radical-mediated acetaldehyde formation by model reactions of dietary components: effects of meat, wine, cooking oil and coffee

Alcohol consumption and the ingestion of red meat and oxidized cooking oil are risk factors of gastric and colorectal cancers. We reported that acetaldehyde (AcAld) is generated from Heme/Mb/Meat-Linoleate-EtO...

Authors: Hiroshi Kasai and Kazuaki Kawai

Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice

Base pair mismatches in genomic DNA can result in mutagenesis, and consequently in tumorigenesis. To investigate how mismatch repair deficiency increases mutagenicity under oxidative stress, we examined the ty...

Authors: Yasunobu Aoki, Mizuki Ohno, Michiyo Matsumoto, Michi Matsumoto, Kenichi Masumura, Takehiko Nohmi and Teruhisa Tsuzuki

Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han population

To evaluate the relationship between transcription factor 7-like 2 (TCF7L2) gene polymorphism and diabetic nephropathy (DN) risk, as well as the effect of gene-environment interactions on DN risk in Chinese Han p...

Authors: Peng Xue, Haihong Cao, Zhimin Ma, Ying Zhou and Nian Wang

New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay

Gene mutation assays in transgenic rodents are useful tools to investigate in vivo mutagenicity in a target tissue. Using a lambda EG10 transgene containing reporter genes, gpt delta transgenic mice and rats have...

Authors: Kenichi Masumura, Tomoko Ando, Akiko Ukai, Sho Fujiwara, Shigeo Yokose, Xinyue You, Takayoshi Suzuki, Hiroyuki Hayashi, Takehiko Nohmi, Hisayoshi Takagi and Masamitsu Honma

Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides

Etheno (and ethano) derivatives of nucleic acid bases have an extra 5-membered ring attached. These were first noted as wyosine bases in tRNAs. Some were fluorescent, and the development of etheno derivatives ...

Authors: F. Peter Guengerich and Pratibha P. Ghodke

Dynamic assessing silica particle-induced pulmonary fibrosis and associated regulation of long non-coding RNA expression in Wistar rats

Exposure to respirable crystalline silica (RCS) can induce accelerated silicosis (AS), a form of silicosis that is more progressive and severe form of silicosis. In this project we aimed to assess processes of...

Authors: Linlin Sai, Xuejie Qi, Gongchang Yu, Juan Zhang, Yuxin Zheng, Qiang Jia and Cheng Peng

Prediction of gene expression regulation by human microRNAs in Plasmodium falciparum

Malaria is a disease annually causing over 400,000 deaths. Deep understanding of molecular and genetic processes underlying its life cycle and pathogenicity is required to efficiently resist it. RNA interferen...

Authors: Alexandr Grinev, Natalya Fokina, Denis Bogomolov, Iza Berechikidze and Yuliya Lazareva

MicroRNAs as the critical regulators of cisplatin resistance in gastric tumor cells

Combined chemotherapeutic treatment is the method of choice for advanced and metastatic gastric tumors. However, resistance to chemotherapeutic agents is one of the main challenges for the efficient gastric ca...

Authors: Amir Sadra Zangouei and Meysam Moghbeli

The role of heterocyclic aromatic amines in colorectal cancer: the evidence from epidemiologic studies

Since Dr. Sugimura’s discovery of heterocyclic aromatic amines (HAA) in broiled fish, many epidemiological studies have been conducted to investigate their role in human cancers, often focusing on colorectal c...

Authors: Loïc Le Marchand

Vitamin D receptor gene polymorphisms and its interactions with environmental factors on renal cell carcinoma risk

We designed a case-control study to investigate the effect of vitamin D receptor gene (VDR) gene single nucleotide polymorphisms (SNPs) and possible gene- environment interaction on the susceptibility of renal...

Authors: Tian Jianhai, Lv Jian, Zhang Long, Wang Wei, Zhang Shumao, Wang Yiming and Li Xiaojuan

Study of the probable genotoxic effects of Zolone (Phosalone) exposure in mice bone marrow derived cells

Approximately, 2 million tonnes of pesticides are utilized annually worldwide. Phosalone (Pln), an organophosphorus pesticide, acts as an insecticide and acaricide to control pests of crops such as nuts, citru...

Authors: Zohre Khodabandeh, Mahmoud Etebari and Mehdi Aliomrani

Association of apolipoprotein B XbaI (rs693) polymorphism and gallstone disease risk based on a comprehensive analysis

Our aim was to investigate the association between XbaI gene polymorphisms in the apolipoprotein B (APOB) gene and gallstone disease (GD) risk through a comparison of the allele and genotype distribution frequenc...

Authors: Haifeng Zhu, Linhai Yu and Linsong Feng

Development of a new quantitative structure–activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDrop™ auto-Modeller™

Food flavors are relatively low molecular weight chemicals with unique odor-related functional groups that may also be associated with mutagenicity. These chemicals are often difficult to test for mutagenicity...

Authors: Toshio Kasamatsu, Airi Kitazawa, Sumie Tajima, Masahiro Kaneko, Kei-ichi Sugiyama, Masami Yamada, Manabu Yasui, Kenichi Masumura, Katsuyoshi Horibata and Masamitsu Honma

New insights on CRISPR/Cas9-based therapy for breast Cancer

CRISPR/Cas9 has revolutionized genome-editing techniques in various biological fields including human cancer research. Cancer is a multi-step process that encompasses the accumulation of mutations that result ...

Authors: Hussein Sabit, Shaimaa Abdel-Ghany, Huseyin Tombuloglu, Emre Cevik, Amany Alqosaibi, Fatma Almulhim and Afnan Al-Muhanaa

Methylation as a critical epigenetic process during tumor progressions among Iranian population: an overview

Cancer is one of the main health challenges and leading causes of deaths in the world. Various environmental and genetic risk factors are associated with tumorigenesis. Epigenetic deregulations are also import...

Authors: Iman Akhlaghipour, Amir Reza Bina, Mohammad Reza Abbaszadegan and Meysam Moghbeli

Formaldehyde exposure and leukemia risk: a comprehensive review and network-based toxicogenomic approach

Formaldehyde is a widely used but highly reactive and toxic chemical. The International Agency for Research on Cancer classifies formaldehyde as a Group 1 carcinogen, based on nasopharyngeal cancer and leukemi...

Authors: Doo Seok Kang, Hyun Soo Kim, Jong-Hyeon Jung, Cheol Min Lee, Yeon-Soon Ahn and Young Rok Seo

Mass spectrometric profiling of DNA adducts in the human stomach associated with damage from environmental factors

A comprehensive understanding of DNA adducts, one of the most plausible origins of cancer mutations, is still elusive, especially in human tissues in clinical settings. Recent technological developments have f...

Authors: Ippei Ohnishi, Yuji Iwashita, Yuto Matsushita, Shunsuke Ohtsuka, Takashi Yamashita, Keisuke Inaba, Atsuko Fukazawa, Hideto Ochiai, Keigo Matsumoto, Nobuhito Kurono, Yoshitaka Matsushima, Hiroki Mori, Shioto Suzuki, Shohachi Suzuki, Fumihiko Tanioka and Haruhiko Sugimura

In vivo comet assay in rabbit corneal epithelial cells following ocular instillation with genotoxic compounds

The in vivo comet assay is used to evaluate the genotoxic potential of compounds by detecting DNA strand breaks in cells isolated from animal tissue. The comet assay of hepatocytes is well established; however, t...

Authors: Haruna Tahara, Yoshinori Yamagiwa, Yu Haranosono and Masaaki Kurata

Standard protocol for the PIGRET assay, a high-throughput reticulocyte Pig-a assay with an immunomagnetic separation, used in the interlaboratory trial organized by the Mammalian Mutagenicity Study Group of the Japanese Environmental Mutagen and Genome Society

The PIGRET assay is one of the Pig-a assays targeting reticulocytes (RETs), an in vivo genotoxicity evaluation method using flow cytometry with endogenous reporter glycosylphosphatidylinositol anchor protein. The...

Authors: Satsuki Chikura, Takafumi Kimoto, Satoru Itoh, Hisakazu Sanada, Shigeharu Muto and Katsuyoshi Horibata

Radio-adaptive response and correlation of non-homologous end joining repair gene polymorphisms [XRRC5 (3R/2R/1R/0R), XRCC6(C/G) and XRCC7 (G/T)] in human peripheral blood mononuclear cells exposed to gamma radiation

Radio-adaptive response (RAR) is transient phenomena, where cells conditioned with a small dose (priming) of ionizing radiation shows significantly reduced DNA damage with a subsequent high challenging dose. T...

Authors: Shridevi Shelke and Birajalaxmi Das

Cancer interception by interceptor molecules: mechanistic, preclinical and human translational studies with chlorophylls

Before ‘cancer interception’ was first advocated, ‘interceptor molecules’ had been conceived as a sub-category of preventive agents that interfered with the earliest initiation steps in carcinogenesis. Three d...

Authors: Roderick H. Dashwood

Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS

Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species differences in metabolism, genome structure, and DNA repair systems. Mutagen...

Authors: Manabu Yasui, Takayuki Fukuda, Akiko Ukai, Jiro Maniwa, Tadashi Imamura, Tsuneo Hashizume, Haruna Yamamoto, Kaori Shibuya, Kazunori Narumi, Yohei Fujiishi, Emiko Okada, Saori Fujishima, Mika Yamamoto, Naoko Otani, Maki Nakamura, Ryoichi Nishimura…

Correction to: Species diversity and molecular analysis of opportunistic Mycobacterium, Nocardia and Rhodococcus isolated from the hospital environment in a developing country, a potential resources for nosocomial infection

An amendment to this paper has been published and can be accessed via the original article.

Authors: Marzieh Siavashifar, Fatemeh Rezaei, Tahereh Motallebirad, Davood Azadi, Abdorrahim Absalan, Zahra Naserramezani, Mohadeseh Golshani, Morteza Jafarinia and Kazem Ghaffari

The ACE and ACTN3 polymorphisms in female soccer athletes

We investigated the association of ACE I/D and ACTN3 R577X polymorphisms with the performance of Chinese elite female soccer athletes for the first time.

Authors: Qi Wei

Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice

Acrylamide (AA) is a rodent carcinogen and classified by the IARC into Group 2A (probable human carcinogen). AA has been reported to induce mutations in transgenic rodent gene mutation assays (TGR assays), the...

Authors: Soichiro Hagio, Naho Tsuji, Satoshi Furukawa, Kazuya Takeuchi, Seigo Hayashi, Yusuke Kuroda, Masamitsu Honma and Kenichi Masumura

Panel of significant risk factors predicts early stage gastric cancer and indication of poor prognostic association with pathogens and microsatellite stability

There are very few studies covering the epidemiological risk factors associated with Epstein Barr Virus (EBV) and Microsatellite stability for Gastric Cancer (GC) cases. Early diagnosis of GC through epidemiologi...

Authors: Payel Chakraborty, Souvik Ghatak, Saia Chenkual, Lalawmpuii Pachuau, John Zohmingthanga, Zothankima Bawihtlung, Lalfakzuala Khenglawt, Jeremy L. Pautu, Arindam Maitra, Lalchhandama Chhakchhuak and Nachimuthu Senthil Kumar

Species diversity and molecular analysis of opportunistic Mycobacterium, Nocardia and Rhodococcus isolated from the hospital environment in a developing country, a potential resources for nosocomial infection

Hospital environmental resources have a significant role in cross-transmission of opportunistic pathogens such as actinomycetes species to the patients. Actinomycetes have a remarkable capability to survive in...

Authors: Marzieh Siavashifar, Fatemeh Rezaei, Tahereh Motallebirad, Davood Azadi, Abdorrahim Absalan, Zahra Naserramezani, Mohadeseh Golshani, Morteza Jafarinia and Kazem Ghaffari