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  1. Rosmarinic acid (RA) has a wide range of beneficial effects on human health. On the other hand, RA has been reported to induce metal-mediated reactive oxygen species (ROS) generation and DNA damage. However, i...

    Authors: Hatasu Kobayashi, Yuichiro Hirao, Shosuke Kawanishi, Shinya Kato, Yurie Mori, Mariko Murata and Shinji Oikawa
    Citation: Genes and Environment 2024 46:13
  2. Sinonasal adenocarcinoma is a rare cancer, encompassing two different entities, the intestinal-type sinonasal adenocarcinoma (ITAC) and the non-intestinal-type sinonasal adenocarcinoma (non-ITAC). Occurrence o...

    Authors: Lauri J. Sipilä, Riku Katainen, Mervi Aavikko, Janne Ravantti, Iikki Donner, Rainer Lehtonen, Ilmo Leivo, Henrik Wolff, Reetta Holmila, Kirsti Husgafvel-Pursiainen and Lauri A. Aaltonen
    Citation: Genes and Environment 2024 46:12
  3. An in vitro micronucleus assay is a standard genotoxicity test. Although the technique and interpretation of the results are simple, manual counting of the total and micronucleus-containing cells in a microsco...

    Authors: Hiromi Yoda, Kazuya Abe, Hideya Takeo, Takeji Takamura-Enya and Ayumi Koike-Takeshita
    Citation: Genes and Environment 2024 46:11
  4. As a natural extraction, astaxanthin is gaining increasing attention because of its safety and anti-tumor properties. It has been reported to participate in the progression of various types of cancer such as g...

    Authors: Yajia Xu and Chengyi Jiang
    Citation: Genes and Environment 2024 46:10
  5. Authors: Augustin Nzitakera, Jean Bosco Surwumwe, Ella Larissa Ndoricyimpaye, Schifra Uwamungu, Delphine Uwamariya, Felix Manirakiza, Marie Claire Ndayisaba, Gervais Ntakirutimana, Benoit Seminega, Vincent Dusabejambo, Eric Rutaganda, Placide Kamali, François Ngabonziza, Rei Ishikawa, Belson Rugwizangoga, Yuji Iwashita…
    Citation: Genes and Environment 2024 46:9

    The original article was published in Genes and Environment 2024 46:8

  6. Gastric cancer is the sixth most frequently diagnosed cancer and third in causing cancer-related death globally. The most frequently mutated gene in human cancers is TP53, which plays a pivotal role in cancer ini...

    Authors: Augustin Nzitakera, Jean Bosco Surwumwe, Ella Larissa Ndoricyimpaye, Schifra Uwamungu, Delphine Uwamariya, Felix Manirakiza, Marie Claire Ndayisaba, Gervais Ntakirutimana, Benoit Seminega, Vincent Dusabejambo, Eric Rutaganda, Placide Kamali, François Ngabonziza, Rei Ishikawa, Belson Rugwizangoga, Yuji Iwashita…
    Citation: Genes and Environment 2024 46:8

    The Correction to this article has been published in Genes and Environment 2024 46:9

  7. Carbendazim (methyl 2-benzimidazolecarbamate, CASRN: 10605-21-7) exhibits spindle poisoning effects and is widely used as a fungicide. With respect to genotoxicity, carbendazim is deemed to be non-mutagenic in...

    Authors: Takako Iso, Kenichiro Suzuki, Yasumasa Murata, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Akihiko Hirose, Kenichi Masumura and Mariko Matsumoto
    Citation: Genes and Environment 2024 46:7
  8. Previously, we have reported on the two curcuminoid analogues with piperidone derivatives, namely FLDP-5 and FLDP-8 have more potent anti-proliferative and anti-migration effects than curcumin. In this study, ...

    Authors: Nur Syahirah Che Razali, Kok Wai Lam, Nor Fadilah Rajab, A. Rahman A. Jamal, Nurul Farahana Kamaludin and Kok Meng Chan
    Citation: Genes and Environment 2024 46:4
  9. A micronucleus test is generally used to evaluate the genotoxic potential of chemicals. Exaggerated erythropoiesis, as occurs following bleeding, may induce an unexpected increase in micronucleus frequency. Th...

    Authors: Yuki Okada, Satsuki Chikura, Takafumi Kimoto and Takeshi Iijima
    Citation: Genes and Environment 2024 46:3
  10. Non-SMC condensin I complex subunit D2 (NCAPD2) belongs to the chromosomal structural maintenance family. While the different contribution of NCAPD2 to chromosome in mitosis have been thoroughly investigated, ...

    Authors: Linyuan Feng, Yang Yang, Zhenhua Lin, Minghua Cui, Aihua Jin and Aili Cui
    Citation: Genes and Environment 2024 46:2

    The Correction to this article has been published in Genes and Environment 2024 46:6

  11. Gastric cancer (GC) is a common malignancy with its morbidity increasing worldwide. Hence, it is imperative to develop effective treatments. Studies have shown that metformin has potential antitumor effects. T...

    Authors: Rui Chen, Jianhui Chen, Miaoliang Chen, Shenkang Zhou and Pinlu Jiang
    Citation: Genes and Environment 2024 46:1
  12. Selenium (Se) is an essential micronutrient for humans, but its deficiency as well as toxicity affects large number of people worldwide. Plantago ovata, a commercially important medicinal plant, is mainly cultiva...

    Authors: Sankalan Dey and Sarmistha Sen Raychaudhuri
    Citation: Genes and Environment 2023 45:38
  13. DNA damage response (DDR) and repair are vital for safeguarding genetic information and ensuring the survival and accurate transmission of genetic material. DNA damage, such as DNA double-strand breaks (DSBs),...

    Authors: Shun Matsuda, Tsuyoshi Ikura and Tomonari Matsuda
    Citation: Genes and Environment 2023 45:37
  14. The number of breast cancer patients is increasing worldwide. Furthermore, breast cancer often develops in young people, even those only in their 30s, who play a central role in their families and society. Res...

    Authors: Takahiro Tsukioki, Seema A. Khan and Tadahiko Shien
    Citation: Genes and Environment 2023 45:35
  15. The Malaysian Society of Toxicology (MySOT), founded in 2010, emerged as a response to the growing need for a collective and interdisciplinary effort to study the effects of substances on human health, and the...

    Authors: Nurul Farahana Kamaludin, Firdaus Kamarulzaman, Rozaini Abdullah, Kok Meng Chan and Salmaan Hussain Inayat-Hussain
    Citation: Genes and Environment 2023 45:34
  16. Carcinogenic risk assessment studies have been repeatedly improved and are still being debated to find a goal. Evaluation might be changed if new approaches would be applied to some chemicals which means that ...

    Authors: Masami Yamada, Takayoshi Suzuki, Arihiro Kohara and Masamitsu Honma
    Citation: Genes and Environment 2023 45:33
  17. Non-Small Cell Lung Cancer displays several genetic mutations including epidermal growth factor receptor. This study's objective was to determine if the EGFR exon19 rs121913438 and exon21 rs121434568 variation...

    Authors: Omali Y. El-khawaga, Mohammed F. Al-azzawy, Afaf M. ElSaid, Sherif Refaat and Aliaa N. El-Dawa
    Citation: Genes and Environment 2023 45:32
  18. Aflatoxin B1 (AFB1) is a mycotoxin produced by several species of Aspergillus fungi which can cause liver cancer in animals and humans. This study aims to perform the risk assessment of AFB1 in herbal medicines a...

    Authors: Siti Soleha Ab Dullah, Mohd Redzwan Sabran, Ab Hamid Hasiah and Rozaini Abdullah
    Citation: Genes and Environment 2023 45:31
  19. Mutagenicity, the ability of chemical agents to cause mutations and potentially lead to cancer, is a critical aspect of substance safety assessment for protecting human health and the environment. Metabolic en...

    Authors: Kazuki Izawa, Masataka Tsuda, Takayoshi Suzuki, Masamitsu Honma and Kei-ichi Sugiyama
    Citation: Genes and Environment 2023 45:30
  20. tert-Butyl hydroperoxide (TBHP; CAS 75–91-2), a hydroperoxide, is mainly used as a polymerization initiator to produce polyethylene, polyvinyl chloride, and unsaturated polyester. It is a high-production chemical...

    Authors: Yasumasa Murata, Kenichiro Suzuki, Yoshiyuki Shigeta, Takako Iso, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Akihiko Hirose, Kenichi Masumura and Mariko Matsumoto
    Citation: Genes and Environment 2023 45:29
  21. The species of genus Macaranga are widely found in Malaysian secondary forests and has been used as an alternative for treating varieties of illness. Studies have shown that the medicinal properties of this genus...

    Authors: Ee Ling Siew, Lishantini Pearanpan, Zhafri Zamkhuri, Fariza Juliana Nordin, Theng Choon Ooi, Kok Meng Chan, Aisyah Salihah Kamarozaman, Norizan Ahmat and Nor Fadilah Rajab
    Citation: Genes and Environment 2023 45:28
  22. The DNA-damaging compounds in heated cooking oil were identified as guanosine adducts. Heated vegetable oil was subjected to deep-frying conditions at 170 °C for 45 min, reacted with isopropylidene guanosine (...

    Authors: Hiroshi Kasai and Kazuaki Kawai
    Citation: Genes and Environment 2023 45:27
  23. The aim of this study was to assess the correlation of spouse selection with short tandem repeats (STRs) in DNA and with the number of fingertip lunulae to investigate the role of heredity in spouse selection.

    Authors: Qi Xia, Ullah Anwar, Yu Weijian, Wang Yingshuai and Liu Hui
    Citation: Genes and Environment 2023 45:26
  24. Prostate cancer is one of the most common cancers among men worldwide and the fourth most common cause of death. The number of prostate cancer cases and deaths is increasing every year because of population ag...

    Authors: Ayako Maeda-Minami, Tomoki Nishikawa, Hideki Ishikawa, Michihiro Mutoh, Kazunori Akimoto, Yutaka Matsuyama, Yasunari Mano and Hiroji Uemura
    Citation: Genes and Environment 2023 45:25
  25. Chronic obstructive pulmonary disease (COPD) is a serious health burden worldwide with high mortality. LncRNA plasmacytoma variant translocation 1 (PVT1) has been illustrated to serve as a biomarker for COPD p...

    Authors: Taoli Fu, Hui Tian, Hui Rong, Ping Ai and Xiaoping Li
    Citation: Genes and Environment 2023 45:24
  26. Evidence showed that N6-methyladenosine (m6A) is strongly associated with male germline development. However, the role of m6A methylation on circRNAs in amphibians remains unknown. In this study, we conducted m6A...

    Authors: Xin Zhang, Linlin Sai, Weiliang Zhang, Xingzheng Kan, Qiang Jia, Cunxiang Bo, Wenhui Yin, Hua Shao, Mingming Han and Cheng Peng
    Citation: Genes and Environment 2023 45:23
  27. Understanding of metabolic processes is a key factor to evaluate biological effects of carcinogen and mutagens. Applicability of fused-grid Template* systems of CYP enzymes (Drug Metab Pharmacokinet 2019, 2020...

    Authors: Yasushi Yamazoe, Norie Murayama, Tomoko Kawamura and Takashi Yamada
    Citation: Genes and Environment 2023 45:22
  28. Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. Exposure to BaP induced D...

    Authors: Huizeng Wang, Bingchun Liu, Hong Chen, Peixin Xu, Huiting Xue and Jianlong Yuan
    Citation: Genes and Environment 2023 45:21
  29. Colorectal cancer (CRC) has been ranked as the second most deadly cancer and the third most diagnosed cancer cases for the year 2020. Specifically for Romania, the number of CRC-related deaths in 2019 was esti...

    Authors: Felix Manirakiza, Hidetaka Yamada, Yuji Iwashita, Keiko Ishino, Rei Ishikawa, Zsolt Kovacs, Eva Osvath, Augustin Nzitakera, Simona Gurzu and Haruhiko Sugimura
    Citation: Genes and Environment 2023 45:20
  30. We investigated the chemopreventive effects of beer, nonalcoholic beers (NABs), and beer-components (glycine betaine (GB)) on NNK-induced lung tumorigenesis in A/J mice, and the possible mechanisms underlying ...

    Authors: Jun Takata, Katsuyuki Kiura, Takamasa Nakasuka, Atsuko Hirabae and Sakae Arimoto-Kobayashi
    Citation: Genes and Environment 2023 45:19
  31. Helicobacter pylori secretes cytotoxin-associated gene A (CagA) into the gastric epithelium, causing gastric mucosal atrophy (GMA) and gastric cancer. In contrast, host cells degrade CagA via autophagy. However, ...

    Authors: Naoyuki Yamaguchi, Takuki Sakaguchi, Hajime Isomoto, Tatsuo Inamine, Ryoya Tsukamoto, Daisuke Fukuda, Ken Ohnita, Tsutomu Kanda, Kayoko Matsushima, Tatsuro Hirayama, Kazuo Yashima and Kazuhiro Tsukamoto
    Citation: Genes and Environment 2023 45:18
  32. Environmental heat stress in dairy cattle leads to poor health, reduced milk production and decreased reproductive efficiency. Multiple genes interact and coordinate the response to overcome the impact of heat...

    Authors: Basavaraj Sajjanar, Mohd Tanzeel Aalam, Owais Khan, Gunturu Narasimha Tanuj, Aditya Prasad Sahoo, Gundallahalli B. Manjunathareddy, Ravi Kumar Gandham, Sujoy K. Dhara, Praveen K. Gupta, Bishnu Prasad Mishra, Triveni Dutt and Gyanendra Singh
    Citation: Genes and Environment 2023 45:17
  33. The human population living in high level natural radiation areas (HLNRAs) of Kerala coast provide unique opportunities to study the biological effects of low dose and low dose rate ionizing radiation below 10...

    Authors: Vinay Jain, Divyalakshmi Saini, D. C. Soren, V. Anil Kumar, P. R. Vivek Kumar, P. K. M. Koya, G. Jaikrishan and Birajalaxmi Das
    Citation: Genes and Environment 2023 45:16
  34. Chronic inflammation induces DNA damage and promotes cell proliferation, thereby increasing the risk of cancer. DNA polymerase κ (Pol κ), involved in translesion DNA synthesis, counteracts mutagenesis induced ...

    Authors: Atsushi Hakura, Hajime Sui, Yuki Seki, Jiro Sonoda, Yusaku Yoshida, Hisayoshi Takagi, Shigeo Yokose, Tomonari Matsuda, Shoji Asakura and Takehiko Nohmi
    Citation: Genes and Environment 2023 45:15
  35. The use of organotypic human tissue models in genotoxicity has increased as an alternative to animal testing. Genotoxicity is generally examined using a battery of in vitro assays such as Ames and micronucleus...

    Authors: Satoru Munakata, Taku Watanabe, Tomohiro Takahashi, Shiori Kimuro, Kanae Ishimori and Tsuneo Hashizume
    Citation: Genes and Environment 2023 45:14
  36. DNA oxidatively damaged by reactive oxygen species is repaired by base excision repair (BER) pathway proteins, with DNA glycosylases removing damaged or mismatched bases in the first step of BER. KsgA is a mul...

    Authors: Yuichiro Hayashi, Masafumi Funakoshi, Kaname Hirosawa and Qiu-Mei Zhang-Akiyama
    Citation: Genes and Environment 2023 45:13
  37. Styrene (CAS 100-42-5) is widely used as polystyrene and acrylonitrile–butadiene–styrene resin such as plastic, rubber, and paint. One of the primary uses of styrene is food utensils and containers, but a smal...

    Authors: Yasumasa Murata, Masakatsu Natsume, Takako Iso, Yoshiyuki Shigeta, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Kenichi Masumura, Akihiko Hirose and Mariko Matsumoto
    Citation: Genes and Environment 2023 45:12
  38. Apoptotic cell death is an important survival system for multicellular organisms because it removes damaged cells. Mutation is also a survival method for dealing with damaged cells in multicellular and also un...

    Authors: Megumi Toyoshima-Sasatani, Fumika Imura, Yuko Hamatake, Akihiro Fukunaga and Tomoe Negishi
    Citation: Genes and Environment 2023 45:11
  39. Exposure to certain chemicals in the environment may contribute to the risk of developing cancer. Although cancer risk from environmental chemical exposure among general populations is considered low compared ...

    Authors: Motoki Iwasaki, Hiroaki Itoh, Norie Sawada and Shoichiro Tsugane
    Citation: Genes and Environment 2023 45:10
  40. The Open Symposium of the Japanese Environmental Mutagen and Genome Society (JEMS) entitled “Analytical technologies to revolutionize the environmental mutagenesis and genome research -From the basics to the c...

    Authors: Naoki Koyama and Akira Sassa
    Citation: Genes and Environment 2023 45:9
  41. Colibactin is a genotoxin produced by Escherichia coli and other Enterobacteriaceae that is believed to increase the risk of colorectal cancer (CRC) of their symbiosis hosts, including human. A peptidase ClbP is ...

    Authors: Tao Zhou, Takayuki Ando, Akihiro Kudo, Michio Sato, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Keiji Wakabayashi and Kenji Watanabe
    Citation: Genes and Environment 2023 45:8
  42. Next-generation RNA sequencing (RNA-Seq) has identified more differentially expressed protein-coding genes (DEGs) and provided a wider quantitative range of expression level changes than conventional DNA micro...

    Authors: Chie Furihata and Takayoshi Suzuki
    Citation: Genes and Environment 2023 45:7
  43. Heat shock proteins (Hsps) are overexpressed in several tumors and contribute to cell proliferation, metastasis, and anticancer drug resistance. Therefore, Hsp inhibitors have enhanced cytotoxicity as chemothe...

    Authors: Takahiro Matsumoto, Erika Ohnishi, Takahiro Kitagawa, Masaya Okayama, Youhei Saito, Hayato Yoshikawa, Tomoe Ohta, Tatsusada Yoshida, Yuji Nakayama and Tetsushi Watanabe
    Citation: Genes and Environment 2023 45:5
  44. Genotoxicity in tissues other than hematopoietic tissues, such as the liver and gastrointestinal (GI) tract, is an important focus in the risk assessment of chemicals in humans. We previously developed a rat m...

    Authors: Wakako Ohyama, Yohei Fujiishi, Emiko Okada, Kazunori Narumi and Makoto Hayashi
    Citation: Genes and Environment 2023 45:4
  45. Non-thermal atmospheric pressure plasma technologies form the core of many scientific advances, including in the electronic, industrial, and biotechnological fields. The use of plasma as a cancer therapy has r...

    Authors: Yang Liu, Yoshimichi Nakatsu, Hiromasa Tanaka, Kazunori Koga, Kenji Ishikawa, Masaharu Shiratani and Masaru Hori
    Citation: Genes and Environment 2023 45:3
  46. Cancer is the primary cause of human mortality in Japan since 1981. Although numerous novel therapies have been developed and applied in clinics, the number of deaths from cancer is still increasing worldwide....

    Authors: Shinya Toyokuni, Yingyi Kong, Yashiro Motooka and Shinya Akatsuka
    Citation: Genes and Environment 2023 45:2

Genes and Environment is an official journal of The Japanese Environmental Mutagen and Genome Society (JEMS).

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