- Updated Aims & Scope: to enhance the quality of Genes and Environment and its contents, the Journal has updated and revised its Aims and Scope.
- The 2021 Journal Citation Reports (JCR) has been released, and we’re pleased to announce 2021 Impact Factor for GE: 2.627.
- G&E Best Paper Award 2021 went to Yang Luan et al. for their paper on PIG-A mutation.
- New article collection: Current topics in China for Environmental Mutagen Research
Screening method toward ClbP-specific inhibitors
Tao Zhou, Takayuki Ando, Akihiro Kudo, Michio Sato, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Keiji Wakabayashi & Kenji Watanabe
Colibactin is a genotoxin produced by Escherichia coli and other Enterobacteriaceae that is believed to increase the risk of colorectal cancer (CRC) of their symbiosis hosts, including human. A peptidase ClbP is the key enzyme for activation of colibactin. Inhibition of ClbP is considered to impede maturation of precolibactin into genotoxic colibactin. Therefore, ClbP-specific inhibitors could potentially prevent the onset of CRC, one of the leading causes of cancer-related deaths in the world. This study intends to establish an efficient screening system for identifying inhibitors that are specific to ClbP.
Read this article Volume 45, Article number: 8 (2023)
Non-CpG sites preference in G:C > A:T transition of TP53 in gastric cancer of Eastern Europe (Poland, Romania and Hungary) compared to East Asian countries (China and Japan)
Hiroko Natsume, Kinga Szczepaniak, Hidetaka Yamada, Yuji Iwashita, Marta Gędek, Jelena Šuto, Keiko Ishino, Rika Kasajima, Tomonari Matsuda, Felix Manirakiza, Augustin Nzitakera, Yijia Wu, Nong Xiao, Qiong He, Wenwen Guo, Zhenming Cai, Tsutomu Ohta, Tıberiu Szekely, Zoltan Kadar, Akiko Sekiyama, Takashi Oshima, Takaki Yoshikawa, Akira Tsuburaya, Nobuhito Kurono, Yaping Wang, Yohei Miyagi, Simona Gurzu, Haruhiko Sugimura
In order to identify the difference of TP53 mutation spectrum in GCs in Eastern Europe and in East Asia, authors sequenced TP53 in GCs from Eastern Europe, Lujiang (China), and Yokohama, Kanagawa (Japan) and identified the feature of TP53 mutations of GC in these regions.
Read this article: Volume 45, Article number: 1 (2023)
Article collections and Special Issues
- Current topics in China for Environmental Mutagen Research
- G&E Best Paper Award collection
- Special Issue in memory of Takashi Sugimura
- Asian Conference on Environmental Mutagens (ACEM2019)
- Article collection: Meeting Reports: collection of various meeting reports published in G&E
- Article collection: Genotoxicity Tests
- JEMS Open Symposia 2017&2018: “Challenges of Young Scientists”
- 10th Anniversary Special Issue
- JEMS Open Symposium 2015: “Life Style and Cancer”
- Asian Conference on Environmental Mutagens (ACEM2014)
About the Editor
Masami Yamada studied bacterial genetics and got a PhD degree from Osaka University. Since 1990, using genetic engineering techniques, she has constructed many strains from standard tester strains for the Ames test at the National Institute of Health Sciences, Tokyo. Such strains are useful for research fields on environmental mutagens.
Strain requests come to her every year from domestic, Asia, Europe, North America, South America, and other countries. Currently, she teaches Biology and Genetic Engineering at National Defense Academy of Japan.
Screening method toward ClbP-specific inhibitors
Short-term in vivo testing to discriminate genotoxic carcinogens from non-genotoxic carcinogens and non-carcinogens using next-generation RNA sequencing, DNA microarray, and qPCR
Report of the online meeting of the 7th Asian Conference on Environmental Mutagens (ACEM), China, November 5-6, 2022
Azaphilones produced by Penicillium maximae with their cell death-inducing activity on Adriamycin-treated cancer cell
Low-dose radiation from A-bombs elongated lifespan and reduced cancer mortality relative to un-irradiated individuals
The micronucleus test—most widely used in vivo genotoxicity test—
Mechanism and regulation of DNA damage recognition in nucleotide excision repair
The health effects of radon and uranium on the population of Kazakhstan
Mechanisms of interstrand DNA crosslink repair and human disorders
Aims and scope
Genes and Environment is an open-access, peer-reviewed journal that aims to accelerate communications among global scientists working in the fields of genes and environment. The journal welcomes papers dealing with those topics that are relevant to the environment, such as mutagenesis and carcinogenesis, genomics and epigenetics, molecular epidemiology and genetic toxicology, and regulatory sciences.
Acknowledgement and information
-Publication of Genes and Environment is partly supported by the Japan Society of Promotion of Science Grant-in-Aid for Publication of Scientific Research Results, aka KAKENHI. (Grant Number 17HP2002).
-Genes and Environment archive of papers published before 2015 are available at: https://www.jstage.jst.go.jp/browse/jemsge
Genes and Environment is an official journal of The Japanese Environmental Mutagen and Genome Society (JEMS).
2.627 - 2-year Impact Factor (2021)
3.150 - 5-year Impact Factor (2021)
0.765 - Source Normalized Impact per Paper (SNIP)
0.449 - SCImago Journal Rank (SJR)
30 days to first decision for all manuscripts (Median)
34 days to first decision for reviewed manuscripts only (Median)
141,941 downloads (2021)
133 Altmetric mentions (2021)