Genes and Environment

Confirmation of Di(2-ethylhexyl) phthalate-induced micronuclei by repeated dose liver micronucleus assay: focus on evaluation of liver micronucleus assay in young rats

Miyuki Shigano, Rie Takashima, Kensuke Satomoto, Henri Sales, Ryoko Harada & Shuichi Hamada  

Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer commonly used in a wide variety of products, including medical devices. It is rapidly metabolized in the liver into various metabolites upon absorption through oral ingestion, dermal absorption, and inhalation. DEHP is classified as a non-genotoxic hepatocarcinogen in rodents, as its chronic exposure has been associated with the development of liver cancer in these animals, but most genotoxicity studies have been negative. Epidemiologic studies in humans suggest that long-term high intakes of DEHP may be a risk factor for liver dysfunction.

Read this article: Volume 46, Article number: 17 (2024)

Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques

Kazuki Izawa, Masataka Tsuda, Takayoshi Suzuki, Masamitsu Honma & Kei-ichi Sugiyama 

Mutagenicity, the potential of chemicals to cause mutations and cancer, is crucial for safety assessments. In vivo animal models, particularly rats, are essential due to their similar metabolic pathways to humans and higher responsiveness to carcinogens. Transgenic rodents (TGRs) are commonly used in mutation assays but are labor-intensive and limited to detecting transgene mutations. A new method for directly detecting in vivo mutagenicity in rats is needed, with next-generation sequencing (NGS) based error-corrected sequencing showing promise.

Read this article: Volume 45, Article number: 30 (2023)

• Article Collection of Papers Related to Oxidatively Damaged Bases Dedicated to Susumu Nishimura
• Research on Genes and Environment by the Malaysian Society of Toxicology 
• Lessons Learned from Japanese Association for Cancer Prevention and Future Opportunities
• Current topics in China for Environmental Mutagen Research
• G&E Best Paper Award collection
• Special Issue in memory of Takashi Sugimura 
• Asian Conference on Environmental Mutagens (ACEM2019)
• Article collection: Meeting Reports: collection of various meeting reports published in G&E
• Article collection: Genotoxicity Tests
• JEMS Open Symposia 2017&2018: “Challenges of Young Scientists”
• 10th Anniversary Special Issue
• JEMS Open Symposium 2015: “Life Style and Cancer”
• Asian Conference on Environmental Mutagens (ACEM2014)

Editor-in-Chief

Masami Yamada studied bacterial genetics and got a PhD degree from Osaka University. Since 1990, using genetic engineering techniques, she has constructed many strains from standard tester strains for the Ames test at the National Institute of Health Sciences, Tokyo. Such strains are useful for research fields on environmental mutagens.
Strain requests come to her every year from domestic, Asia, Europe, North America, South America, and other countries. Currently, she teaches Biology and Genetic Engineering at National Defense Academy of Japan.

APC Discount for JEMS members
Members of Japanese Environmental Mutagen and Genome Society(JEMS)  are entitled to receive discount on Article Processing Charge. 

Free APC for researchers in Asia
We may offer a full APC waiver to the submissions from the countries where Asian Association of the Environmental Mutagen Societies (AAEMS)–partnering societies are located (excluding Japan). Those countries are Australia, China, India, Iran, South Korea, Philippines and Thailand. Please contact EIC (editor@j-ems.org) before submission.

To request APC discount
Authors are no longer requested to submit membership code during submission.
Please take following step to receive APC discount.
1) After manuscript submission, corresponding author informs EIC (editor@j-ems.org) of the manuscript number and membership number. 
2) When the manuscript was accepted for publication, author receives URL and asked to complete post-acceptance process. 
3) During post-acceptance process author requests APC discount by requsting 'Shared Support' on journal partner page.
4) EIC approves the request and discount is granted. 
5) Author pays discounted APC. 

*those authors who were offered full APC coverage by the editor (for invited/solicited papers), should select 'Prepay for invited papers' to receive full coverage. 

see also
-Changes in Submission Process (in Japanese)
-Post acceptance workflow process (Author Journey)