Genes and Environment

DNA polymerase κ suppresses inflammation and inflammation-induced mutagenesis and carcinogenic potential in the colon of mice

Atsushi Hakura, Hajime Sui, Yuki Seki, Jiro Sonoda, Yusaku Yoshida, Hisayoshi Takagi, Shigeo Yokose, Tomonari Matsuda, Shoji Asakura & Takehiko Nohmi 

Chronic inflammation induces DNA damage and promotes cell proliferation, thereby increasing the risk of cancer. DNA polymerase κ (Pol κ), involved in translesion DNA synthesis, counteracts mutagenesis induced by inflammation in the colon of mice. In the present study, we examined whether Pol κ suppressed inflammation-induced colon tumorigenesis by treating inactivated Polk knock-in (Polk−/−) mice with dextran sulfate sodium (DSS), an inducer of colon inflammation.

Read this article: Volume 45, Article number: 15 (2023)

Development of a micronucleus test using the EpiAirway™ organotypic human airway model

Satoru Munakata, Taku Watanabe, Tomohiro Takahashi, Shiori Kimuro, Kanae Ishimori & Tsuneo Hashizume

The article discusses the development of a micronucleus (MN) test using EpiAirway™, an organotypic human airway model, as an alternative method to assess genotoxicity. The study aimed to address the challenge of low cell proliferation in airway models, which affects their ability to induce micronuclei, a biomarker of genotoxicity.

Read this article Volume 45, Article number: 14 (2023)

• Lessons Learned from Japanese Association for Cancer Prevention and Future Opportunities
• Current topics in China for Environmental Mutagen Research
• G&E Best Paper Award collection
• Special Issue in memory of Takashi Sugimura 
• Asian Conference on Environmental Mutagens (ACEM2019)
• Article collection: Meeting Reports: collection of various meeting reports published in G&E
• Article collection: Genotoxicity Tests
• JEMS Open Symposia 2017&2018: “Challenges of Young Scientists”
• 10th Anniversary Special Issue
• JEMS Open Symposium 2015: “Life Style and Cancer”
• Asian Conference on Environmental Mutagens (ACEM2014)

Masami Yamada studied bacterial genetics and got a PhD degree from Osaka University. Since 1990, using genetic engineering techniques, she has constructed many strains from standard tester strains for the Ames test at the National Institute of Health Sciences, Tokyo. Such strains are useful for research fields on environmental mutagens.
Strain requests come to her every year from domestic, Asia, Europe, North America, South America, and other countries. Currently, she teaches Biology and Genetic Engineering at National Defense Academy of Japan.

APC Discount for JEMS members
Members of Japanese Environmental Mutagen and Genome Society(JEMS)  are entitled to receive discount on Article Processing Charge. 

Free APC for researchers in Asia
We now offer a full APC waiver to the submissions from the countries where Asian Association of the Environmental Mutagen Societies (AAEMS)–partnering societies are located (excluding Japan). Those countries are Australia, China, India, Iran, South Korea, Philippines and Thailand.

To request APC discount (new process as from March 2023)
Authors are no longer requested to submit membership code during submission.
Please take following step to receive APC discount.
1) After manuscript submission, corresponding author informs EIC (editor@j-ems.org) of the manuscript number and membership number. 
2) When the manuscript was accepted for publication, author receives URL and asked to complete post-acceptance process. 
3) During post-acceptance process author requests APC discount by requsting 'Shared Support' on journal partner page.
4) EIC approves the request and discount is granted. 
5) Author pays discounted APC. 

see also
-information for JEMS members (in Japanese) 
-Post acceptance workflow process (Author Journey)

*those authors who were offered full APC coverage by the editor (for invited/solicited papers), please select 'Prepay for invited papers' to receive full coverage.