Genes and Environment

In vivo genotoxicity assessment of a multiwalled carbon nanotube in a mouse ex vivo culture

Katsuyoshi Horibata, Hironao Takasawa, Motoki Hojo, Yuhji Taquahashi, Miyuki Shigano, Satoshi Yokota, Norihiro Kobayashi, Kei-ichi Sugiyama, Masamitsu Honma & Shuichi Hamada 

Multiwalled carbon nanotubes (MWCNTs) are suspected lung carcinogens because their shape and size are similar to asbestos. Various MWCNT types are manufactured; however, only MWNT-7 is classified into Group 2B by The International Agency for Research on Cancer. MWNT-7’s carcinogenicity is strongly related to inflammatory reactions.  In this study, to investigate in vivo MWNT-7 genotoxicity on various endpoints, authors attempted to develop a lung micronucleus assay through ex vivo culture targeting the cellular fraction of Clara cells and alveolar Type II (AT-II) cells, known as the initiating cells of lung cancer.

Read this article Volume 44, Article number: 24 (2022)

PIG-A gene mutation as a genotoxicity biomarker in polycyclic aromatic hydrocarbon-exposed barbecue workers

Yiyi Cao, Jing Xi, Chuanxi Tang, Ziying Yang, Weiying Liu, Xinyue You, Nannan Feng, Xin Yu Zhang, Jingui Wu, Yingxin Yu & Yang Luan

The PIG-A gene mutation assay is a valuable tool for measuring in vivo gene mutations in blood cells. The human PIG-A assay, used as a potential genotoxicity biomarker, is minimally invasive, sensitive, and cost-efficient; however, the relationship between carcinogen exposure and PIG-A mutations is not well understood.
Authors investigated the genotoxic effect of red blood cells using PIG-A assay and lymphocyte cytokinesis-block micronucleus test in barbecue restaurant workers (N = 70) exposed to polycyclic aromatic hydrocarbons (PAHs) and self-identified healthy control subjects (N = 56). Urinary PAH metabolites were measured to evaluate internal exposure levels.

Read this article: Volume 43, Article number: 54 (2021)

Current topics in China for Environmental Mutagen Research
Collection published 28 Dec 2021
G&E Best Paper Award collection
Collection published 25 August 2021
Special Issue in memory of Takashi Sugimura 
Collection published 23 July 2021
Asian Conference on Environmental Mutagens (ACEM2019)
Collection published 19 April 2021
Article collection: Meeting Reports: collection of various meeting reports published in G&E
Collection published 23 March 2020 
Article collection: Genotoxicity Tests
Collection published 28 June 2019
JEMS Open Symposia 2017&2018: “Challenges of Young Scientists”
Collection published 14 February 2019
10th Anniversary Special Issue
Collection published 1 July 2016
JEMS Open Symposium 2015: “Life Style and Cancer”
Collection published: 22 January 2016
Asian Conference on Environmental Mutagens (ACEM2014)
Collection published: 1 August 2015

Masami Yamada studied bacterial genetics and got a PhD degree from Osaka University. Since 1990, using genetic engineering techniques, she has constructed many strains from standard tester strains for the Ames test at the National Institute of Health Sciences, Tokyo. Such strains are useful for research fields on environmental mutagens.
Strain requests come to her every year from domestic, Asia, Europe, North America, South America, and other countries. Currently, she teaches Biology and Genetic Engineering at National Defense Academy of Japan.

APC Discount for JEMS members
Members of Japanese Environmental Mutagen and Genome Society(JEMS)  are entitled to receive discount on Article Processing Charge. 

Free APC for researchers in Asia
We now offer a full APC waiver to the submissions from the countries where Asian Association of the Environmental Mutagen Societies (AAEMS)–partnering societies are located (excluding Japan). Those countries are Australia, China, India, Iran, South Korea, Philippines and Thailand.

Request of APC discount/full waiver code
In order to receive discount/full waiver, author has to  submit the waiver code during the process of manuscript submission. Authors eligible for these arrangements should contact the journal (editor@j-ems.org) prior to submission and request the code. 

About JEMS
The mission of the Japanese Environmental Mutagen and Genome Society (JEMS) is to discover how environmental mutagens affect all organisms, and to promote and apply this knowledge to protect human health and our environment. JEMS was founded in 1972, and since then the society has hosted annual conferences and open symposia on timely topics. The society is a member of the Asian Association of the Environmental Mutagen Societies and the International Association of Environmental Mutagenesis and Genomics Societies.