- Updated Aims & Scope: to enhance the quality of Genes and Environment and its contents, the Journal has updated and revised its Aims and Scope.
- The 2021 Journal Citation Reports (JCR) has been released, and we’re pleased to announce 2021 Impact Factor for GE: 2.627.
- G&E Best Paper Award 2021 went to Yang Luan et al. for their paper on PIG-A mutation.
- New article collection: Current topics in China for Environmental Mutagen Research
In vivo genotoxicity assessment of a multiwalled carbon nanotube in a mouse ex vivo culture
Katsuyoshi Horibata, Hironao Takasawa, Motoki Hojo, Yuhji Taquahashi, Miyuki Shigano, Satoshi Yokota, Norihiro Kobayashi, Kei-ichi Sugiyama, Masamitsu Honma & Shuichi Hamada
Multiwalled carbon nanotubes (MWCNTs) are suspected lung carcinogens because their shape and size are similar to asbestos. Various MWCNT types are manufactured; however, only MWNT-7 is classified into Group 2B by The International Agency for Research on Cancer. MWNT-7’s carcinogenicity is strongly related to inflammatory reactions. In this study, to investigate in vivo MWNT-7 genotoxicity on various endpoints, authors attempted to develop a lung micronucleus assay through ex vivo culture targeting the cellular fraction of Clara cells and alveolar Type II (AT-II) cells, known as the initiating cells of lung cancer.
Read this article Volume 44, Article number: 24 (2022)
[Featured Article]: G&E Best Paper Award 2021
PIG-A gene mutation as a genotoxicity biomarker in polycyclic aromatic hydrocarbon-exposed barbecue workers
Yiyi Cao, Jing Xi, Chuanxi Tang, Ziying Yang, Weiying Liu, Xinyue You, Nannan Feng, Xin Yu Zhang, Jingui Wu, Yingxin Yu & Yang Luan
The PIG-A gene mutation assay is a valuable tool for measuring in vivo gene mutations in blood cells. The human PIG-A assay, used as a potential genotoxicity biomarker, is minimally invasive, sensitive, and cost-efficient; however, the relationship between carcinogen exposure and PIG-A mutations is not well understood.
Authors investigated the genotoxic effect of red blood cells using PIG-A assay and lymphocyte cytokinesis-block micronucleus test in barbecue restaurant workers (N = 70) exposed to polycyclic aromatic hydrocarbons (PAHs) and self-identified healthy control subjects (N = 56). Urinary PAH metabolites were measured to evaluate internal exposure levels.
Read this article: Volume 43, Article number: 54 (2021)
Current topics in China for Environmental Mutagen Research
Collection published 28 Dec 2021
G&E Best Paper Award collection
Collection published 25 August 2021
Special Issue in memory of Takashi Sugimura
Collection published 23 July 2021
Asian Conference on Environmental Mutagens (ACEM2019)
Collection published 19 April 2021
Article collection: Meeting Reports: collection of various meeting reports published in G&E
Collection published 23 March 2020
Article collection: Genotoxicity Tests
Collection published 28 June 2019
JEMS Open Symposia 2017&2018: “Challenges of Young Scientists”
Collection published 14 February 2019
10th Anniversary Special Issue
Collection published 1 July 2016
JEMS Open Symposium 2015: “Life Style and Cancer”
Collection published: 22 January 2016
Asian Conference on Environmental Mutagens (ACEM2014)
Collection published: 1 August 2015
About the Editor
Masami Yamada studied bacterial genetics and got a PhD degree from Osaka University. Since 1990, using genetic engineering techniques, she has constructed many strains from standard tester strains for the Ames test at the National Institute of Health Sciences, Tokyo. Such strains are useful for research fields on environmental mutagens.
Strain requests come to her every year from domestic, Asia, Europe, North America, South America, and other countries. Currently, she teaches Biology and Genetic Engineering at National Defense Academy of Japan.
Low-dose radiation from A-bombs elongated lifespan and reduced cancer mortality relative to un-irradiated individuals
Aims and scope
Genes and Environment is an open-access, peer-reviewed journal that aims to accelerate communications among global scientists working in the fields of genes and environment. The journal welcomes papers dealing with those topics that are relevant to the environment, such as mutagenesis and carcinogenesis, genomics and epigenetics, molecular epidemiology and genetic toxicology, and regulatory sciences.
Acknowledgement and information
-Publication of Genes and Environment is partly supported by the Japan Society of Promotion of Science Grant-in-Aid for Publication of Scientific Research Results, aka KAKENHI. (Grant Number 17HP2002).
-Genes and Environment archive of papers published before 2015 are available at: https://www.jstage.jst.go.jp/browse/jemsge
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34 days to first decision for reviewed manuscripts only (Median)
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