Genes and Environment

Evaluation of a 4-day repeated-dose micronucleus test in rat glandular stomach and colon using aneugens and non-genotoxic non-carcinogens

Emiko Okada, Yohei Fujiishi, Kazunori Narumi & Wakako Ohyama   

Following the previous study to develop rodent gastrointestinal (GI) tract micronucleus (MN) test using the glandular stomach and/or colon and demonstrate that the test method could detect genotoxic stomach and/or colon carcinogens with target organ specificity, authors further evaluated the sensitivity and specificity of the MN test for the rat glandular stomach and colon using three aneugens (colchicine, vinblastine sulfate, and docetaxel hydrate) and two non-genotoxic non-carcinogens (sodium chloride and sucrose).

Read this article Volume 44, Article number: 12 (2022)

A local QSAR model based on the stability of nitrenium ions to support the ICH M7 expert review on the mutagenicity of primary aromatic amines

Ayaka Furukawa, Satoshi Ono, Katsuya Yamada, Nao Torimoto, Mahoko Asayama & Shigeharu Muto 

Aromatic amines, often used as intermediates for pharmaceutical synthesis, may be mutagenic and therefore pose a challenge as metabolites or impurities in drug development. However, predicting the mutagenicity of aromatic amines using commercially available, quantitative structure–activity relationship (QSAR) tools is difficult and often requires expert review. In this study, we developed a shareable QSAR tool based on nitrenium ion stability.

Read this article: Volume 44, Article number: 10 (2022)

Current topics in China for Environmental Mutagen Research
Collection published 28 Dec 2021
G&E Best Paper Award collection
Collection published 25 August 2021
Special Issue in memory of Takashi Sugimura 
Collection published 23 July 2021
Asian Conference on Environmental Mutagens (ACEM2019)
Collection published 19 April 2021
Article collection: Meeting Reports: collection of various meeting reports published in G&E
Collection published 23 March 2020 
Article collection: Genotoxicity Tests
Collection published 28 June 2019
JEMS Open Symposia 2017&2018: “Challenges of Young Scientists”
Collection published 14 February 2019
10th Anniversary Special Issue
Collection published 1 July 2016
JEMS Open Symposium 2015: “Life Style and Cancer”
Collection published: 22 January 2016
Asian Conference on Environmental Mutagens (ACEM2014)
Collection published: 1 August 2015

Masami Yamada studied bacterial genetics and got a PhD degree from Osaka University. Since 1990, using genetic engineering techniques, she has constructed many strains from standard tester strains for the Ames test at the National Institute of Health Sciences, Tokyo. Such strains are useful for research fields on environmental mutagens.
Strain requests come to her every year from domestic, Asia, Europe, North America, South America, and other countries. Currently, she teaches Biology and Genetic Engineering at National Defense Academy of Japan.

APC Discount for JEMS members
Members of Japanese Environmental Mutagen and Genome Society(JEMS)  are entitled to receive discount on Article Processing Charge. 

Free APC for researchers in Asia
We now offer a full APC waiver to the submissions from the countries where Asian Association of the Environmental Mutagen Societies (AAEMS)–partnering societies are located (excluding Japan). Those countries are Australia, China, India, Iran, South Korea, Philippines and Thailand.

Request of APC discount/full waiver code
In order to receive discount/full waiver, author has to  submit the waiver code during the process of manuscript submission. Authors eligible for these arrangements should contact the journal (editor@j-ems.org) prior to submission and request the code. 

About JEMS
The mission of the Japanese Environmental Mutagen and Genome Society (JEMS) is to discover how environmental mutagens affect all organisms, and to promote and apply this knowledge to protect human health and our environment. JEMS was founded in 1972, and since then the society has hosted annual conferences and open symposia on timely topics. The society is a member of the Asian Association of the Environmental Mutagen Societies and the International Association of Environmental Mutagenesis and Genomics Societies.