- Meeting Report "the open symposium of the Japanese Environmental Mutagen Society (JEMS) in 2019" released on 13 September.
- New Article Collection Genotoxicity Tests released on 28 June.
- Genes and Environment accepted for inclusion in Clarivate Analytics's Emerging Source Citation Index (ESCI).
[Pick Up] High-content imaging analyses of γH2AX-foci and micronuclei in TK6 cells elucidated genotoxicity of chemicals and their clastogenic/aneugenic mode of action
The in vitro micronucleus (MN) test is an important component of a genotoxicity test battery. However, scoring micronucleated cells by microscope is laborious and time-consuming. A high-throughput assay system for detecting MNi automatically has long been desired in the fields of pharmaceutical development or environmental risk monitoring. UsingγH2AX, a sensitive marker of DNA double strand breaks, Takeiri et al. established a high-content imaging assay that automatically detected MNi and simultaneously measured γH2AX foci in human lymphoblastoid TK6 cells. The assay provided information on the aneugenic/clastogenic mode of action.
Article collection: Genotoxicity Tests
Collection published 28 June 2019
JEMS Open Symposia 2017&2018: “Challenges of Young Scientists”
Collection published 14 February 2019
10th Anniversary Special Issue
Collection published 1 July 2016
JEMS Open Symposium 2015: “Life Style and Cancer”
Collection published: 22 January 2016
Asian Conference on Environmental Mutagens (ACEM2014)
Collection published: 1 August 2015
Aims and scope
Genes and Environment is an open access, peer-reviewed journal that aims to accelerate communications among global scientists working in the field of genes and environment. The journal publishes articles across a broad range of topics including environmental mutagenesis and carcinogenesis, environmental genomics and epigenetics, molecular epidemiology, genetic toxicology and regulatory sciences.
About the Editor
Masami Yamada studied bacterial genetics and got a PhD degree from Osaka University. Since 1990, using genetic engineering techniques, she has constructed many strains from standard tester strains for the Ames test at the National Institute of Health Sciences, Tokyo. Such strains are useful for research fields on environmental mutagens.
Strain requests come to her every year from domestic, Asia, Europe, North America, South America, and other countries. Currently, she teaches Biology and Genetic Engineering at National Defense Academy of Japan.
Acknowledgement and information
-Publication of Genes and Environment is partly supported by the Japan Society of Promotion of Science Grant-in-Aid for Publication of Scientific Research Results, aka KAKENHI. (Grant Number 17HP2002).
-Genes and Environment archive of papers published before 2015 are available at: https://www.jstage.jst.go.jp/browse/jemsge
31 days to first decision for received manuscripts only
31 days to first decision for all manuscripts
80 days from submission top acceptance
33 days from acceptance to publication
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