Genes and Environment

Formation of the mutagenic DNA lesion 1,N²-ethenoguanine induced by heated cooking oil and identification of causative agents

Hiroshi Kasai & Kazuaki Kawai

Epidemiological studies have consistently shown that diet plays a significant role in developing human cancer. Notably, the consumption of fried food has been associated with an increased risk of various cancers. Information about the carcinogens and DNA-damaging agents in fried foods remains limited, except for acrolein and acrylamide, both being classified as Group 2A (i.e., probable human carcinogens) by the International Agency for Research on Cancer.
This study sought to identify the cancer-causing agents by extensively investigating guanine modifications induced by heated cooking oil as a model for DNA damage.

Read this article Volume 45, Article number: 27 (2023) 

Analysis of nucleotide insertion opposite urea and translesion synthesis across urea by DNA polymerases

Taishu Kawada, Katsuhito Kino, Kyousuke Tokorodani, Ryuto Anabuki, Masayuki Morikawa, Takanobu Kobayashi, Kazuaki Ohara, Takayuki Ohshima & Hiroshi Miyazawa 

In this article, authors describe their studies of nucleotide incorporations and translesion synthesis in relation to Ua with DNA polymerases α, δ, ε, η, ζ and Dpo4. Also, authors confirmed nucleotide incorporation and extension in relation to Ua using Kf exo− and DNA polymerase β.

Read this article: Volume 44, Article number: 7 (2022)

• Lessons Learned from Japanese Association for Cancer Prevention and Future Opportunities
• Current topics in China for Environmental Mutagen Research
• G&E Best Paper Award collection
• Special Issue in memory of Takashi Sugimura 
• Asian Conference on Environmental Mutagens (ACEM2019)
• Article collection: Meeting Reports: collection of various meeting reports published in G&E
• Article collection: Genotoxicity Tests
• JEMS Open Symposia 2017&2018: “Challenges of Young Scientists”
• 10th Anniversary Special Issue
• JEMS Open Symposium 2015: “Life Style and Cancer”
• Asian Conference on Environmental Mutagens (ACEM2014)

Masami Yamada studied bacterial genetics and got a PhD degree from Osaka University. Since 1990, using genetic engineering techniques, she has constructed many strains from standard tester strains for the Ames test at the National Institute of Health Sciences, Tokyo. Such strains are useful for research fields on environmental mutagens.
Strain requests come to her every year from domestic, Asia, Europe, North America, South America, and other countries. Currently, she teaches Biology and Genetic Engineering at National Defense Academy of Japan.

APC Discount for JEMS members
Members of Japanese Environmental Mutagen and Genome Society(JEMS)  are entitled to receive discount on Article Processing Charge. 

Free APC for researchers in Asia
We now offer a full APC waiver to the submissions from the countries where Asian Association of the Environmental Mutagen Societies (AAEMS)–partnering societies are located (excluding Japan). Those countries are Australia, China, India, Iran, South Korea, Philippines and Thailand.

To request APC discount (new process as from March 2023)
Authors are no longer requested to submit membership code during submission.
Please take following step to receive APC discount.
1) After manuscript submission, corresponding author informs EIC (editor@j-ems.org) of the manuscript number and membership number. 
2) When the manuscript was accepted for publication, author receives URL and asked to complete post-acceptance process. 
3) During post-acceptance process author requests APC discount by requsting 'Shared Support' on journal partner page.
4) EIC approves the request and discount is granted. 
5) Author pays discounted APC. 

*those authors who were offered full APC coverage by the editor (for invited/solicited papers), should select 'Prepay for invited papers' to receive full coverage. 

see also
-Changes in Submission Process (in Japanese)
-Post acceptance workflow process (Author Journey)