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[Featured Article]

Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques

Kazuki Izawa, Masataka Tsuda, Takayoshi Suzuki, Masamitsu Honma & Kei-ichi Sugiyama 


Mutagenicity, the potential of chemicals to cause mutations and cancer, is crucial for safety assessments. In vivo animal models, particularly rats, are essential due to their similar metabolic pathways to humans and higher responsiveness to carcinogens. Transgenic rodents (TGRs) are commonly used in mutation assays but are labor-intensive and limited to detecting transgene mutations. A new method for directly detecting in vivo mutagenicity in rats is needed, with next-generation sequencing (NGS) based error-corrected sequencing showing promise.

Read this article: Volume 45, Article number: 30 (2023)

[Featured Article]

Rosmarinic acid, a natural polyphenol, has a potential pro-oxidant risk via NADH-mediated oxidative DNA damage

Hatasu Kobayashi, Yuichiro Hirao, Shosuke Kawanishi, Shinya Kato, Yurie Mori, Mariko Murata & Shinji Oikawa 

Rosmarinic acid

Rosmarinic acid (RA) has a wide range of beneficial effects on human health. On the other hand, RA has been reported to induce metal-mediated reactive oxygen species (ROS) generation and DNA damage. However, its mechanism remains unknown. In this study, to clarify the underlying mechanism, authors analyzed metal-mediated DNA damage in isolated DNA treated with RA and its analog isorinic acid.

Read this article: Volume 46, Article number: 13 (2024)

Article collections and Special Issues

About the Editor

New Content Item


Masami Yamada studied bacterial genetics and got a PhD degree from Osaka University. Since 1990, using genetic engineering techniques, she has constructed many strains from standard tester strains for the Ames test at the National Institute of Health Sciences, Tokyo. Such strains are useful for research fields on environmental mutagens.
Strain requests come to her every year from domestic, Asia, Europe, North America, South America, and other countries. Currently, she teaches Biology and Genetic Engineering at National Defense Academy of Japan.

Information for authors

APC Discount for JEMS members
Members of Japanese Environmental Mutagen and Genome Society(JEMS)  are entitled to receive discount on Article Processing Charge

Free APC for researchers in Asia
We may offer a full APC waiver to the submissions from the countries where Asian Association of the Environmental Mutagen Societies (AAEMS)–partnering societies are located (excluding Japan). Those countries are Australia, China, India, Iran, South Korea, Philippines and Thailand. Please contact EIC ( before submission.

To request APC discount
Authors are no longer requested to submit membership code during submission.
Please take following step to receive APC discount.
1) After manuscript submission, corresponding author informs EIC ( of the manuscript number and membership number. 
2) When the manuscript was accepted for publication, author receives URL and asked to complete post-acceptance process
3) During post-acceptance process author requests APC discount by requsting 'Shared Support' on journal partner page.
4) EIC approves the request and discount is granted. 
5) Author pays discounted APC. 

*those authors who were offered full APC coverage by the editor (for invited/solicited papers), should select 'Prepay for invited papers' to receive full coverage. 

see also
-Changes in Submission Process (in Japanese)
-Post acceptance workflow process (Author Journey)


Aims and scope

Genes and Environment is an open-access, peer-reviewed journal that aims to accelerate communications among global scientists working in the fields of genes and environment. The journal welcomes papers dealing with those topics that are relevant to the environment, such as mutagenesis and carcinogenesis, genomics and epigenetics, molecular epidemiology and genetic toxicology, and regulatory sciences.

About JEMS
The mission of the Japanese Environmental Mutagen and Genome Society (JEMS) is to discover how environmental mutagens affect all organisms, and to promote and apply this knowledge to protect human health and our environment. JEMS was founded in 1972, and since then the society has hosted annual conferences and open symposia on timely topics. The society is a member of the Asian Association of the Environmental Mutagen Societies and the International Association of Environmental Mutagenesis and Genomics Societies.

Acknowledgement and information

-Publication of Genes and Environment is partly supported by the Japan Society of Promotion of Science Grant-in-Aid for Publication of Scientific Research Results, aka KAKENHI. (Grant Number 17HP2002).

-Genes and Environment archive of papers published before 2015 are available at:

Genes and Environment is an official journal of The Japanese Environmental Mutagen and Genome Society (JEMS).

Citation Impact 2023
Journal Impact Factor: 2.7
5-year Journal Impact Factor: 2.3
Source Normalized Impact per Paper (SNIP): 0.798
SCImago Journal Rank (SJR): 0.593

Speed 2023
Submission to first editorial decision (median days): 7
Submission to acceptance (median days): 91

Usage 2023
Downloads: 314,686
Altmetric mentions: 181