Evans HJ, Neary GJ, Williamson FS. The relative biological efficiency of single doses of fast neutrons and gamma-rays on Vicia faba roots and the effect of oxygen: Part II. Chromosome damage: the production of micronuclei. Int J Rad Biol. 1959;3:216–29.
Google Scholar
Boller K, Schmid W. Chemische Mutagenese beim Sauger. Das knochenmark des Chinesischen Hamsters als in vivo-testsystem. Haematologische befunde nach Behandlung mit Trenimon. Humangenetik. 1970;11:35–54.
CAS
PubMed
Google Scholar
Schmid W. The micronucleus test. Mutat Res. 1975;31:9–15.
Article
CAS
PubMed
Google Scholar
Heddle JA. A rapid in vivo test for chromosomal damage. Mutat Res. 1973;18:187–90.
Article
CAS
PubMed
Google Scholar
Coutryman PI, Heddle JA. The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Mutat Res. 1976;41:321–32.
Article
Google Scholar
Fenech M, Morley AA. Measurement of micronuclei in lymphocytes. Mutat Res. 1985;147:29–36.
Article
CAS
PubMed
Google Scholar
Cole RJ, Taylor NA, Cole J, Arlett CF. Transplacental effects of chemical mutagens detected by the micronucleus test. Nature (London). 1979;227:317–8.
Article
Google Scholar
King M-T, Wild D. Transplacental mutagenesis: The micronucleus test on fetal mouse blood. Hum Genet. 1979;51:183–94.
Article
CAS
PubMed
Google Scholar
Cole RJ, Taylor N, Cole J, Henderson L, Arlett CF. Short-term tests for transplacentally active carcinogens: Sensitivity of the transplacental micronucleus test to diethylnitrosamine. Mutat Res. 1982;104:165–71.
Article
CAS
PubMed
Google Scholar
MacGregor JT, Wehr CM, Gould DH. Clastogen-induced micronuclei in peripheral blood erythrocytes: The basis of a improve micronucleus test. Environ Mutagen. 1980;2:509–14.
Article
CAS
PubMed
Google Scholar
Lahdetie J, Parvinen M. Meiotic micronuclei induced by X-rays in early spermatids of the rat. Mutat Res. 1981;81:103–15.
Article
CAS
PubMed
Google Scholar
Tates AD, Dietrich AJJ, de Vogel N, Newteboom I, Bos A. A micronucleus method for detection of meiotic micronuclei in male germ cells of mammals. Mutat Res. 1983;121:131–8.
Article
CAS
PubMed
Google Scholar
Heddle JA, Hite M, Kirkhart B, Mavournin K, MacGregor JT, Newell GW, Salamone MF. The induction of micronuclei as a measure of genotoxicity: A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res. 1983;123:527–49.
Google Scholar
Ashby J, de Serres FJ, Shelby MD, Margolin BH, Ishidate Jr M, Becking GC, editors. Evaluation of short term tests for carcinogens. Report of the International Programme on Chemical Safety's Collaborative Study on in vivo assays. New York: Cambridge Univ. Press; 1988.
Google Scholar
Hayashi M, Sofuni T, Ishidate Jr M. An application of acridine orange fluorescent staining to the micronucleus test. Mutat Res. 1983;120:241–7.
Article
CAS
PubMed
Google Scholar
MacGregor JT, Wehr CM, Langlois RG. A simple fluorescent staining procedure for micronuclei and RNA in erythrocytes using Hoechst 33258 and pyronin Y. Mutat Res. 1983;120:269–75.
Article
CAS
PubMed
Google Scholar
The Collaborative Study Group for the Micronucleus Test. Sex difference in the micronucleus test. Mutat Res. 1986;172:151–63.
Article
Google Scholar
The Collaborative Study Group for the Micronucleus Test. Strain difference in the micronucleus test. Mutat Res. 1988;204:307–16.
Article
Google Scholar
Hayashi M, Sutou S, Shimada H, Sato S, Sasaki YF, Wakata A. Difference between intraperitoneal and oral gavage application in the micronucleus test: The 3rd collaborative study by CSGMT/JEMS-MMS. Mutat Res. 1989;223:329–44.
Article
CAS
PubMed
Google Scholar
The Collaborative Study Group for the Micronucleus Test. Single versus multiple dosing in the micronucleus test: The summary of the fourth collaborative study by CSGMT/JEMS·MMS. Mutat Res. 1990;234:205–22.
Article
Google Scholar
The Collaborative Study Group for the Micronucleus Test. Micronucleus test with mouse peripheral blood erythrocytes by acridine orange supravital staining: The summary report of the 5th collaborative study by CSGMT/JEMS·MMS. Mutat Res. 1992;278:83–98.
Article
Google Scholar
Sato S, Taketomi M, Nakajima M, Kitazawa M, Shimada H, Ito S, Igarashi M, Higashikuni N, Sutou S, Sasaki YF, Hayashi M, Sofuni T, Higashiguchi T, Nito S, Kondo Y, Honda S, Hayashi M, Shinagawa Y, Nakajima E, Oka Y, Shimoi K, Hokabe Y, Morita A, Kinae N, Takeuchi M, Hirono H, Yamamura E, Tamai K. Effect of aging on spontaneous micronucleus frequencies in peripheral blood of nine mouse strains: the results of the 7th collaborative study organized by CSGMT/MMS. Mutat Res. 1995;338:51–7.
Article
CAS
PubMed
Google Scholar
The Collaborative Study Group for the Micronucleus Test. Individual data in the Results of the 7th collaborative study organized by CSGMT/JEMS·MMS. MMS Commun. 1995;3:117–31.
Google Scholar
Morita T, Asano N, Awogi T, Sasaki YF, Sato S, Shimada H, Sutou S, Suzuki T, Wakata A, Sofuni T, Hayashi M.. Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (Groups 1, 2A, and 2B). The summary report of the 6th collaborative study by CSGMT/JEMS·MMS. Mutat Res. 1997;389:3–122.
Article
PubMed
Google Scholar
Wakata A, Miyamae Y, Sato S, Suzuki T, Morita T, Asano N, Awogi T, Kondo K, Hayashi M. Evaluation of the rat micronucleus test with bone marrow and peripheral blood: Summary of the 9th collaborative study by CSGMT/JEMS·MMS. Environ Mol Mutagen. 1998;32:84–100.
Article
CAS
PubMed
Google Scholar
Hamada S, Sutou S, Morita T, Wakata A, Asanami S, Hosoya S, Ozawa S, Kondo K, Nakajima M, Shimada H, Osawa K, Kondo Y, Asano N, Sato S, Tamura H, Yajima N, Marshall R, Moore C, Blakey DH, Schechtman LM, Weaver JL, Torous DK, Proudlock R, Ito S, Namiki C, Hayashi M.. Evaluation of the rodent micronucleus assay by a 28-day-treatment protocol: Summary of the 13th collaborative study by CSGMT/JEMS · MMS. Environ Mol Mutagen. 2001;37:93–110.
Article
CAS
PubMed
Google Scholar
Suzuki H, Ikeda N, Kobayashi K, Terashima Y, Shimada Y, Suzuki T, Hagiwara T, Hatakeyama S, Nagaoka K, Yoshida J, Saito Y, Tanaka J, Hayashi M. Evaluation of liver and peripheral blood micronucleus assays with 9 chemicals using young rats: A study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)—Mammalian Mutagenicity Study Group (MMS). Mutat Res. 2005;583:133–45.
Article
CAS
PubMed
Google Scholar
Hamada S, Ohyama W, Takashima R, Shimada K, Matsumoto K, Kawakami S, Uno F, Sui H, Shimada Y, Imamura T, Matsumura S, Sanada H, Inoue K, Muto S, Ogawa I, Hayashi A, Takayanagi T, Ogiwara Y, Maeda A, Okada E, Terashima Y, Takasawa H, Narumi K, Wako Y, Kawasako K, Sano M, Ohashi N, Morita T, Kojima H, Honma M, Hayashi M. Evaluation of the repeated-dose liver and gastrointestinal tract micronucleus assays with 22 chemicals using young adult rats: Summary of the collaborative study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/The Japanese Environmental Mutagen Society (JEMS) – Mammalian Mutagenicity Study Group (MMS). Mutat Res. 2015;780-781:2–17.
Article
CAS
Google Scholar
Guidance on genotoxicity testing and data interpretation for pharmaceuticals intended for human use. In: ICH Guideline. 2011. http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S2_R1/Step4/S2R1_Step4.pdf. Accessed 13 May 2016.
OECD Test Guideline TG-474. 2014. http://www.oecd.org/env/ehs/testing/draft_tg474_second_commenting_round.pdf. Accessed 13 May 2016.
Thomson EJ, Perry PE. The identification of micronucleated chromosomes: a possible assay for aneuploidy. Mutagenesis. 1988;3:415–8.
Article
CAS
PubMed
Google Scholar
Yamamoto KI, Kikuchi Y. A comparison of diameters of micronuclei induced by clastogens and spindle poisons. Mutat Res. 1980;71:127–31.
Article
CAS
PubMed
Google Scholar
Hogstedt B, Karlsson A. The size of micronuclei in human lymphocytes varies according to inducing agent used. Mutat Res. 1985;156:229–32.
Article
CAS
PubMed
Google Scholar
Degrassi F, Tanzarella C. Immunofluorescent staining of kinetochores in micronuclei: a new assay for the detection of aneuploidy. Mutat Res. 1988;203:339–45.
Article
CAS
PubMed
Google Scholar
Hayashi M, Maki-Paakkanen J, Tanabe H, Honma M, Suzuki T, Matsuoka A, Mizusawa H, Sofuni T. Isolation of micronuclei from mouse blood and fluorescence in situ hybridization with a mouse centromeric DNA probe. Mutat Res. 1994;307:245–51.
Article
CAS
PubMed
Google Scholar
Hutter KJ, Stöhr M. Rapid detection of mutagen induced micronucleated erythrocytes by flow cytometry. Histochem. 1982;75:353–62.
Article
CAS
Google Scholar
Hayashi M, Norppa H, Sofuni T, Ishidate Jr M. Mouse bone marrow micronucleus test using flow cytometry. Mutagenesis. 1992;7:251–6.
Article
CAS
PubMed
Google Scholar
Hayashi M, Norppa H, Sofuni T, Ishidate Jr M. Flow cytometric micronucleus test with mouse peripheral erythrocytes. Mutagenesis. 1992;7:257–64.
Article
CAS
PubMed
Google Scholar
Dertinger SD et al. Flow cytometric scoring of micronucleated erythrocytes: an efficient platform for assessing in vivo cytogenetic damage. Mutagenesis. 2011;26:139–45.
Article
CAS
PubMed
Google Scholar
Romagna F, Staniforth CD. The automated bone marrow micronucleus test. Mutat Res. 1989;213:91–104.
Article
CAS
PubMed
Google Scholar
Asano N, Katsuma Y, Tamura H, Higashikuni N, Hayashi M. An automated new technique for scoring the rodent micronucleus assay: computerized image analysis of acridine orange supravitally stained peripheral blood cells. Mutat Res. 1998;404:149–54.
Article
CAS
PubMed
Google Scholar
Abramsson-Zetterberg L, Grawé J, Zetterberg G. The micronucleus test in rat erythrocytes from bone marrow, spleen and peripheral blood: The response to low doses of ionizing radiation, cyclophosphamide and vincristine determined by flow cytometry. Mutat Res. 1999;423:113–24.
Article
CAS
PubMed
Google Scholar
Mavournin KH, Blakey DH, Cimino MC, Salamone MF, Heddle JA. The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene Tox Program. Mutat Res. 1990;239:29–80.
Article
CAS
PubMed
Google Scholar
Hayashi M, Tice RR, MacGregor JT, Anderson D, Blakey DH, Kirsh-Volders M, Oleson FB, Pacchierotti F, Romagna F, Shimada H, Sutou S, Vannier B. In vivo rodent erythrocyte micronucleus assay. Mutat Res. 1994;312:293–304.
Article
CAS
PubMed
Google Scholar
Hayashi M, MacGregor JT, Gatehouse DG, Adler I-D, Blakey DH, Dertinger SD, Krishna G, Morita T. Russo A, Sutou S. In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring. Environ Mol Mutagen. 2000;35:234–52.
Article
CAS
PubMed
Google Scholar
Hayashi M, MacGregor JT, Gatehouse DG, Blakey DH, Dertinger SD, Abramsson-Zetterberg L, Krishna G, Morita T, Russo A, Asano N, Suzuki H, Ohyama W, Gibson D. In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test. Mutat Res. 2007;627:10–30.
Article
CAS
PubMed
Google Scholar
Torous D, Asano, Tometsko C, Sugunan S, Dertinger S, Morita T, Hayashi M. Performance of flow cytometric analysis for the micronucleus assay— a reconstruction model using serial dilutions of malaria infected cells with normal mouse peripheral blood. Mutagenesis. 2006;21:11–3.
Asano N, Torous D, Tometsko C, Dertinger S, Morita T, Hayashi M. Practical threshold for micronucleated reticulocyte induction observed for low doses of mitomycin C, Ara-C and colchicine. Mutagenesis. 2006;21:15–20.
Article
CAS
PubMed
Google Scholar
Pfuhler S, Kirkland D, Kasper P, Hayashi M, Vanparys P, Carmichael P, Dertinger S, Eastmond D, Elhajouji A, Krul C, Rothfuss A, Schoening G, Smith A, Speit G, Thomas C, van Benthem J, Corvi R. Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities—Report from an ECVAM workshop. Mutat Res. 2009;680:31–42.
Article
CAS
PubMed
Google Scholar