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Table 3 Genotype and minor allele frequencies and Hardy Weinberg equilibrium for the selected TLR4 polymorphisms comparing children with asymptomatic and clinical malaria

From: Toll-like receptor (TLR4) Asp299Gly and Thr399Ile polymorphisms in relation to clinical falciparum malaria among Nigerian children: a multisite cross-sectional immunogenetic study in Lagos

TLR4 SNP Genotype/Minor allele Study group *OR (95 % CI) P HWE, χ2 (P)
Total Clinical malaria ASM
(N = 279) (n = 187) (n = 92)
Asp299Gly Asp299Asp, % (Fraction) 88.5 (247/279) 87.7 (164/187) 90.2 (83/92) 1   Clinical malaria = 4.89 (<0.05)
Asp299Gly, % (Fraction) 10.8 (28/279) 10.7 (20/187) 8.7 (8/92)    
Gly299Gly, % (Fraction) 0.7 (4/279) 1.6 (3/187) 1.1 (1/92) 1.29 (0.57-2.92) 0.54 ASM = 0.11 (>0.05)
MAF 6.5 (36/558) 7 (26/374) 5.4 (10/184)   0.49  
Thr399Ile Thr399Thr, % (Fraction) 94.9 (265/279) 94.7 (177/187) 95.7 (88/92) 1   Clinical malaria = 1.35 (>0.05)
Thr399Ile, % (Fraction) 4.3 (12/279) 4.3 (8/187) 4.3 (4/92)    
Ile399Ile, % (Fraction) 0.8 (2/279) 1 (2/187) 0 (0/92) 1.24 (0.58-4.08 0.49 ASM = 0.21 (>0.05)
MAF, % (Fraction) 2.9 (16/558) 3.2 (12/374) 2.2 (4/184)   0.50  
  1. MAF = Minor allele frequency, OR = odd ratio, 95 % CI = 95 % confidence intervals, n = number of children screened per sub-group; N = total number of children screened. *OR was calculated after pooling heterozygous and homozygous mutant genotype frequencies; ASM = asymptomatic malaria; P < 0.05 was considered to be significant