Table 3 Genotype and minor allele frequencies and Hardy Weinberg equilibrium for the selected TLR4 polymorphisms comparing children with asymptomatic and clinical malaria
TLR4 SNP | Genotype/Minor allele | Study group | *OR (95 % CI) | P | HWE, χ2 (P) | ||
|---|---|---|---|---|---|---|---|
Total | Clinical malaria | ASM | |||||
(N = 279) | (n = 187) | (n = 92) | |||||
Asp299Gly | Asp299Asp, % (Fraction) | 88.5 (247/279) | 87.7 (164/187) | 90.2 (83/92) | 1 | Clinical malaria = 4.89 (<0.05) | |
Asp299Gly, % (Fraction) | 10.8 (28/279) | 10.7 (20/187) | 8.7 (8/92) | ||||
Gly299Gly, % (Fraction) | 0.7 (4/279) | 1.6 (3/187) | 1.1 (1/92) | 1.29 (0.57-2.92) | 0.54 | ASM = 0.11 (>0.05) | |
MAF | 6.5 (36/558) | 7 (26/374) | 5.4 (10/184) | 0.49 | |||
Thr399Ile | Thr399Thr, % (Fraction) | 94.9 (265/279) | 94.7 (177/187) | 95.7 (88/92) | 1 | Clinical malaria = 1.35 (>0.05) | |
Thr399Ile, % (Fraction) | 4.3 (12/279) | 4.3 (8/187) | 4.3 (4/92) | ||||
Ile399Ile, % (Fraction) | 0.8 (2/279) | 1 (2/187) | 0 (0/92) | 1.24 (0.58-4.08 | 0.49 | ASM = 0.21 (>0.05) | |
MAF, % (Fraction) | 2.9 (16/558) | 3.2 (12/374) | 2.2 (4/184) | 0.50 | |||