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Table 4 Specific mutant frequency of G:C to A:T transition and G:C to T:A transversion on gpt gene from the lung of B[a]P-instilled and control mice

From: Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages

Type of mutation in the gpt gene Control (months) B[a]P (months)
  3 11 24 3 11 24
  Specific mutant frequency* (×10−5)   
G:C → A:T 0.27 0.44 0.35 0.25 0.42 0.92**
G:C → T:A 0.12 0.18 0.14 1.39 0.40 0.41
  1. *Specific mutant frequency = [Average mutant frequency in Table 1] × [% mutant of G:C to A:T transition or G:C to T:A transversion of corresponding group in Table 2]
  2. **P < 0.001 (Chi-square test) for comparison between B[a]P-instilled mice and age-matched control mice