Fig. 1

Mutant frequencies in the cII gene in mammary gland and ovary of mice. Big Blue transgenic mice were exposed to E2 during the first 5 days of life and/or treated with DMBA at 6 months of age. Significant differences were found between DMBA and control groups, between E2 + DMBA and control groups, between DMBA and E2-only groups, and between E2 + DMBA and E2-only groups, respectively, for the both tissues (* p < 0.05 and ** p < 0.01). The data represent the mean ± S.E.M. from 3 ~ 5 mice in each group