Fig. 3From: Induction of action-at-a-distance mutagenesis by 8-oxo-7,8-dihydroguanine in DNA pol λ-knockdown cellsOverall distribution of the substitution mutations detected in the supF gene, based on the data shown in Table 1. The sequence of the upper strand of the plasmid is shown. The mutations obtained with the control and anti-pol λ siRNAs are shown above and below the sequence, respectively. a The control plasmid containing a G:C pair at position 122. b The plasmid containing a GO:C pair at position 122. The underlined G in panel B represents the 122nd position, and the targeted mutations are not depictedBack to article page