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Fig. 6 | Genes and Environment

Fig. 6

From: Progerin, the protein responsible for the Hutchinson-Gilford progeria syndrome, increases the unrepaired DNA damages following exposure to ionizing radiation

Fig. 6

Rejuvenation of HGPS cells by enforced expression of human telomerase gene (hTERT). a Envelope-surface ratio (ESR) of nuclei. b Expression level of progerin. c Number of 53BP1 foci per nucleus in HGPS cells (AG11513 cells at PDs ~23) and the hTERT-introduced cells (PDs ~110). d Number of unrepairable repair foci at 12-Gy/ 1-month. e Proposed model of telomerase mediated rejuvenation

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Genes and Environment

ISSN: 1880-7062

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