Fig. 6From: Progerin, the protein responsible for the Hutchinson-Gilford progeria syndrome, increases the unrepaired DNA damages following exposure to ionizing radiationRejuvenation of HGPS cells by enforced expression of human telomerase gene (hTERT). a Envelope-surface ratio (ESR) of nuclei. b Expression level of progerin. c Number of 53BP1 foci per nucleus in HGPS cells (AG11513 cells at PDs ~23) and the hTERT-introduced cells (PDs ~110). d Number of unrepairable repair foci at 12-Gy/ 1-month. e Proposed model of telomerase mediated rejuvenationBack to article page