Fig. 1
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs41021-016-0028-x/MediaObjects/41021_2016_28_Fig1_HTML.gif)
Metabolic-activation pathway of methyleugenol (ME) leading to the production of mutagenic metabolites. ME is metabolized by cytochrome P450 (CYP) to 1’-HME. Subsequent sulfoconjugation of 1’-HME by sulfotransferase (SULT) leads to the production of highly reactive electrophiles that can form DNA adducts