Fig. 1From: Modified Ames test using a strain expressing human sulfotransferase 1C2 to assess the mutagenicity of methyleugenolMetabolic-activation pathway of methyleugenol (ME) leading to the production of mutagenic metabolites. ME is metabolized by cytochrome P450 (CYP) to 1’-HME. Subsequent sulfoconjugation of 1’-HME by sulfotransferase (SULT) leads to the production of highly reactive electrophiles that can form DNA adductsBack to article page