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Table 1 Genotoxicity data on 4-methylimidazole

From: Genotoxicity assessment of 4-methylimidazole: regulatory perspectives

Test System and conditions Dose Result Reference
Bacterial reverse mutation test Salmonella typhimurium TA97, TA98, TA100, TA1535, TA1537 and TA1538. With and without S9 from rat or hamster liver. 100 – 10,000 μg/plate Negative [1, 5]
Bacterial reverse mutation test Escherihia coli WP2 uvrA. With and without S9. 9.77 – 5000 μg/plate Negative [5]
Bacterial reverse mutation test Salmonella typhimurium TA98, TA100, TA1535, TA1537 and TA102. With and without S9 from rat liver or lung, or mouse liver or lung. 5 – 5000 μg/plate Negative [14]
SAR analysis Three softwares including Osiris, ToxTree and DEREK. Not applicable Negative [13]
Micronucreus assay Male and female mouse peripheral blood. Diet for 92 days. 625 – 10,000 ppm (up to 3200 mg/kg/day for male, 1900 mg/kg/day for female) Negative [1, 5]
Micronucreus assay Male mouse bone marrow. Three intraperitoneal injections. 25 – 200 mg/kg Negative [1, 5]
Micronucreus assay Male rat bone marrow. Three intraperitoneal injections. 25 – 100 mg/kg Negative [1, 5]
  1. SAR structure-activity relationship