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Table 1 Induction of mutations (gpt assay) in the lungs of transgenic rats treated with MWCNTs

From: Absence of in vivo mutagenicity of multi-walled carbon nanotubes in single intratracheal instillation study using F344 gpt delta rats

Compound Dose (mg/kg) Animal No. Colony-forming units Mutants Mutant frequency (×10−6)
0.2% CMC* 0 1 756,000 5 6.61
   2 1,284,000 2 1.56
   3 924,000 0 0.00
   4 720,000 0 0.00
   5 939,000 1 1.06
   6 621,000 0 0.00
   Ave.    1.54
   S.D.    2.57
MWCNT 1 1 1,035,000 2 1.93
   2 810,000 4 4.94
   3 930,000 0 0.00
   4 909,000 2 2.20
   5 951,000 1 1.05
   6 870,000 1 1.15
   Ave.    1.88
   S.D.    1.69
ENU 35.6 1 777,000 1 1.29
   2 894,000 4 4.47
   3 744,000 3 4.03
   4 510,000 1 1.96
   5 567,000 6 10.58
   6 678,000 2 2.95
   Ave.    4.21**
   S.D.    3.34
  1. *CMC, a carboxymethyl cellulose solution (negative control)
  2. **p < 0.05 compared to the control