Table 1 Induction of mutations (gpt assay) in the lungs of transgenic rats treated with MWCNTs
Compound | Dose (mg/kg) | Animal No. | Colony-forming units | Mutants | Mutant frequency (×10−6) |
|---|---|---|---|---|---|
0.2% CMC* | 0 | 1 | 756,000 | 5 | 6.61 |
2 | 1,284,000 | 2 | 1.56 | ||
3 | 924,000 | 0 | 0.00 | ||
4 | 720,000 | 0 | 0.00 | ||
5 | 939,000 | 1 | 1.06 | ||
6 | 621,000 | 0 | 0.00 | ||
Ave. | 1.54 | ||||
S.D. | 2.57 | ||||
MWCNT | 1 | 1 | 1,035,000 | 2 | 1.93 |
2 | 810,000 | 4 | 4.94 | ||
3 | 930,000 | 0 | 0.00 | ||
4 | 909,000 | 2 | 2.20 | ||
5 | 951,000 | 1 | 1.05 | ||
6 | 870,000 | 1 | 1.15 | ||
Ave. | 1.88 | ||||
S.D. | 1.69 | ||||
ENU | 35.6 | 1 | 777,000 | 1 | 1.29 |
2 | 894,000 | 4 | 4.47 | ||
3 | 744,000 | 3 | 4.03 | ||
4 | 510,000 | 1 | 1.96 | ||
5 | 567,000 | 6 | 10.58 | ||
6 | 678,000 | 2 | 2.95 | ||
Ave. | 4.21** | ||||
S.D. | 3.34 |