Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer

Genes and Environment

Table 2 Frequency of CYP1A1 variants among lung cancer patients and control

CYP1A1	Control^a	Cases^a	OR (95% CI)	NSCLC^a	OR (95% CI)	SCLC^a	OR (95% CI)
Variant	n=150	n=149^b	P- value	n=129	P value	n=20	P- value
CYP1A1*2C	19(12.7)	17(11.4)	1.126(0.56–2.26) 0.7	13(10.1)	0.77(0.37–1.63) 0.4	4(20)	1.72(0.52–5.70) 0.3
CYP1A1*4	33(22)	46(30.9)	0.63(0.38–1.06) 0.08	41(31.8)	1.65(0.97–2.82) 0.06	5(25)	1.18 (0.40–3.49) 0.7
CYP1A12C/4	0(0)	4(2.7)	2.03(1.81–2.29) 0.04^c	4(3.1)	2.20(1.93–2.50) 0.02^c	0(0)	–
CYP1A1*1 (wild type)	98(65.3)	82(55)	0.65(0.41–1.04) 0.07	71(55)	0.11(−0.01–0.23) 0.07	11(55)	1.54(0.60, 3.96) 0.3

SCLC small cell lung cancer, NSCLC non-small cell lung cancer
^aData presented as N (%)
^bThe case carrying rare CYP1A1 857 T > C (I286T) variant was excluded from the statistical analysis
^csignificant p

ISSN: 1880-7062