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Table 2 Frequency of CYP1A1 variants among lung cancer patients and control

From: Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer

CYP1A1 Controla Casesa OR (95% CI) NSCLCa OR (95% CI) SCLCa OR (95% CI)
Variant n=150 n=149b P- value n=129 P value n=20 P- value
CYP1A1*2C 19(12.7) 17(11.4) 1.126(0.56–2.26)
0.7
13(10.1) 0.77(0.37–1.63)
0.4
4(20) 1.72(0.52–5.70)
0.3
CYP1A1*4 33(22) 46(30.9) 0.63(0.38–1.06)
0.08
41(31.8) 1.65(0.97–2.82)
0.06
5(25) 1.18 (0.40–3.49)
0.7
CYP1A1*2C/*4 0(0) 4(2.7) 2.03(1.81–2.29)
0.04c
4(3.1) 2.20(1.93–2.50)
0.02c
0(0)
CYP1A1*1
(wild type)
98(65.3) 82(55) 0.65(0.41–1.04)
0.07
71(55) 0.11(−0.01–0.23)
0.07
11(55) 1.54(0.60, 3.96)
0.3
  1. SCLC small cell lung cancer, NSCLC non-small cell lung cancer
  2. aData presented as N (%)
  3. bThe case carrying rare CYP1A1 857 T > C (I286T) variant was excluded from the statistical analysis
  4. csignificant p