Skip to main content

Table 2 Summary of the mutation spectra of TK −/− mutantationsa

From: DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis

  Solvent control MMC
  WT TK+/- KO TK+/- WT TK+/- KO TK +/-
Base substitution
 Transition     
  A:T → G:C 10 (36) 11 (26) 6 (6) 5 (4)
  G:C → A:T 1 (4) 2 (5) 5 (5) 4 (3)
 Transversion
  A:T → T:A 0 (0) 2 (5) 1 (1) 0 (0)
  A:T → C:G 0 (0) 2 (5) 4 (4) 1 (1)
  G:C → T:A 3 (11) 10 (23) 10 (11) 17 (13)
  G:C → C:G 0 (0) 1 (2) 8 (9) 9 (7)
 Tandem
  GG:CC → CT:GA 0 (0) 0 (0) 3 (3) 2 (2)
  GG:CC → TT:AA 0 (0) 0 (0) 8 (9) 6 (5)
  GG:CC → AT:TA 0 (0) 0 (0) 2 (2) 0 (0)
  CA:GT → TG:AC 1 (4) 0 (0) 0 (0) 0 (0)
  AG:TC → CT:GA 0 (0) 0 (0) 0 (0) 1 (1)
 Frameshift (+1) 0 (0) 0 (0) 1 (1) 1 (1)
 Frameshift (+2) 1 (4) 0 (0) 0 (0) 0 (0)
 Frameshift (−1) 0 (0) 0 (0) 0 (0) 2 (2)
 LOH 12 (43) 15 (35) 43 (46) 78 (62)
 Unidentified 0 (0) 0 (0) 2 (2) 0 (0)
 Total 28 (100) 43 (100) 93 (100) 126 (100)
  1. aData are presented as number of clones (ratio), with the results of two independent experiments are aggregated
Back to article page

Genes and Environment

ISSN: 1880-7062

Contact us