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Table 2 Summary of the mutation spectra of TK −/− mutantationsa

From: DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis

 

Solvent control

MMC

 

WT TK+/-

KO TK+/-

WT TK+/-

KO TK +/-

Base substitution

 Transition

    

  A:T → G:C

10 (36)

11 (26)

6 (6)

5 (4)

  G:C → A:T

1 (4)

2 (5)

5 (5)

4 (3)

 Transversion

  A:T → T:A

0 (0)

2 (5)

1 (1)

0 (0)

  A:T → C:G

0 (0)

2 (5)

4 (4)

1 (1)

  G:C → T:A

3 (11)

10 (23)

10 (11)

17 (13)

  G:C → C:G

0 (0)

1 (2)

8 (9)

9 (7)

 Tandem

  GG:CC → CT:GA

0 (0)

0 (0)

3 (3)

2 (2)

  GG:CC → TT:AA

0 (0)

0 (0)

8 (9)

6 (5)

  GG:CC → AT:TA

0 (0)

0 (0)

2 (2)

0 (0)

  CA:GT → TG:AC

1 (4)

0 (0)

0 (0)

0 (0)

  AG:TC → CT:GA

0 (0)

0 (0)

0 (0)

1 (1)

 Frameshift (+1)

0 (0)

0 (0)

1 (1)

1 (1)

 Frameshift (+2)

1 (4)

0 (0)

0 (0)

0 (0)

 Frameshift (−1)

0 (0)

0 (0)

0 (0)

2 (2)

 LOH

12 (43)

15 (35)

43 (46)

78 (62)

 Unidentified

0 (0)

0 (0)

2 (2)

0 (0)

 Total

28 (100)

43 (100)

93 (100)

126 (100)

  1. aData are presented as number of clones (ratio), with the results of two independent experiments are aggregated
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Genes and Environment

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