Fig. 2
From: Giemsa-stained pseudo-micronuclei in rat skin treated with vitamin D3 analog, pefcalcitol
Results of in vivo MN test in rat bone marrow cells obtained 24 h (a) or 48 h (b) after single intravenous administration of pefcalcitol. The bar represents the incidence of micronucleated polychromatic erythrocytes (MNPCE). The line graph indicates the ratio of polychromatic erythrocytes (PCE) to all erythrocytes, which is the total of PCE plus normochromatic erythrocytes (NCE). MNPCE in 2000 or more PCE of each rat were detected, and the ratio of PCE among 1000 or more total erythrocytes (PCE + NCE) were determined. Each bar or dot represents the average of five or four rats, and error bars of SD are presented. ** p < 0.01, significantly different from vehicle control (Student’s t-test). ## p < 0.01, significantly different from vehicle control (Mann-Whitney U-test). MMC was administered intraperitoneally at a dose of 2 mg/kg as a positive control