Table 1 Induction of micronuclei in rat skin cells after single topical application of pefcalcitol
From: Giemsa-stained pseudo-micronuclei in rat skin treated with vitamin D3 analog, pefcalcitol
Treatment | Micronucleated cells (%) | AO negative/Giemsa positive (%) | ||||
|---|---|---|---|---|---|---|
Giemsa positive | AO positive | |||||
Individual | Mean ± SD | Individual | Mean ± SD | Individual | Mean ± SD | |
Vehicle | 0.35 | 0.55 ± 0.14 | 0.30 | 0.44 ± 0.13 | 14 | 20 ± 6 |
0.50 | 0.40 | 20 | ||||
0.55 | 0.40 | 27 | ||||
0.60 | 0.45 | 25 | ||||
0.75 | 0.65 | 13 | ||||
Pefcalcitol 20 mg/kg | 1.15 | 1.15 ± 0.11** | 0.40 | 0.48 ± 0.10 | 65 | 58 ± 11* |
1.15 | 0.55 | 52 | ||||
1.00 | 0.55 | 45 | ||||
1.30 | 0.35 | 73 | ||||
1.15 | 0.55 | 52 | ||||
Mitomycin C 0.2 mg/body | 1.85 | 1.62 ± 0.29** | 1.70 | 1.49 ± 0.31** | 8 | 8 ± 4 |
1.30 | 1.10 | 15 | ||||
2.00 | 1.90 | 5 | ||||
1.50 | 1.40 | 7 | ||||
1.45 | 1.35 | 7 | ||||