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Table 1 Induction of micronuclei in rat skin cells after single topical application of pefcalcitol

From: Giemsa-stained pseudo-micronuclei in rat skin treated with vitamin D3 analog, pefcalcitol

Treatment Micronucleated cells (%) AO negative/Giemsa positive (%)
Giemsa positive AO positive
Individual Mean ± SD Individual Mean ± SD Individual Mean ± SD
Vehicle 0.35 0.55 ± 0.14 0.30 0.44 ± 0.13 14 20 ± 6
0.50 0.40 20
0.55 0.40 27
0.60 0.45 25
0.75 0.65 13
Pefcalcitol 20 mg/kg 1.15 1.15 ± 0.11** 0.40 0.48 ± 0.10 65 58 ± 11*
1.15 0.55 52
1.00 0.55 45
1.30 0.35 73
1.15 0.55 52
Mitomycin C 0.2 mg/body 1.85 1.62 ± 0.29** 1.70 1.49 ± 0.31** 8 8 ± 4
1.30 1.10 15
2.00 1.90 5
1.50 1.40 7
1.45 1.35 7
  1. *p < 0.05, **p < 0.01, significantly increased from vehicle control value (Mann-Whitney U-test)