Fig. 1From: Unique molecular mechanisms for maintenance and alteration of genetic information in the budding yeast Saccharomyces cerevisiae Checkpoint cascade in S. cerevisiae. DNA replication arrest and DNA lesions act as signals and are recognized by sensors to activate the checkpoint pathway. Sensors activate Mec1p kinase, followed by the consecutive phosphorylation of transducers and effectors to induce the expression of DNA damage response genesBack to article page