Fig. 12

Putative mechanisms that contribute to the bias of the mutation rate in the genome. a Difference in the efficiency of the mismatch DNA repair. Mismatch base-pairing by damage-induced replication errors is rapidly repaired in the region adjacent to SUP2, whereas efficiency is lower in the SUP6 adjacent region [88]. b Involvement of replication timing on the chromosome. Fidelity of DNA damage bypass may be determined by availability of TLS polymerases (error-free or error-prone) and induction of Rad5p-mediated recombination-based template switching during cell cycle, those are correlated with ubiquitination status of PCNA (see text for detail) [89, 90, 92,93,94,95,96]