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Fig. 3 | Genes and Environment

Fig. 3

From: Unique molecular mechanisms for maintenance and alteration of genetic information in the budding yeast Saccharomyces cerevisiae

Fig. 3

Regulation of RNR activity by three negative regulators. Sml1p binds to R1 (Rnr1p homodimer) in order to inhibit the catalytic activity of the R1 subunit, whereas Dif1p controls the nuclear localization of the R2 subunit (Rnr2p-Rnr4p heterodimer). Hug1p is induced in response to a replication block and DNA damage, and transiently attenuates increased RNR activity by inhibiting the association of R1 and R2 in the cytoplasm (see text)

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Genes and Environment

ISSN: 1880-7062

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