Table 2 Mutagenicity of MeIQx in urate-null mutants and wild-type flies
From: Increase of somatic cell mutations in oxidative damage-sensitive drosophila
Dose (mM) | Survival (%) | No. of wings | No. of spots (spots/wing) | ||
|---|---|---|---|---|---|
Small | Large | Total | |||
Exp. 1 | |||||
 y v ma-l; mwh × Oregon-R F1 females (uric acid +) | |||||
  0 | 100 | 143 | 11 (0.08) | 6 (0.04) | 17 (0.12) |
  2 | 58 | 89 | 15 (0.19)* | 5 (0.06) | 20 (0.25)* |
  4 | 80 | 126 | 41 (0.33)** | 11 (0.09) | 52 (0.41)** |
 y v ma-l; mwh × y v ma-l F1 females (uric acid -) | |||||
  0 | 100 | 135 | 65 (0.48) | 9 (0.07) | 74 (0.55) |
  2 | 62 | 84 | 63 (0.75)** | 13 (0.15) | 76 (0.90)** |
  4 | 68 | 92 | 90 (0.98)** | 29 (0.32)** | 119 (1.29)** |
Exp. 2 | |||||
 y v ma-l; mwh × Oregon-R F1 females (uric acid +) | |||||
  0 | 100 | 151 | 19 (0.13) | 4 (0.03) | 23 (0.15) |
  0.5 | 68 | 92 | 11 (0.12) | 6 (0.07) | 17 (0.18) |
  1 | 67 | 108 | 31 (0.29)** | 5 (0.05) | 36 (0.33)** |
  2 | 57 | 94 | 28 (0.30)** | 8 (0.09) | 36 (0.38)** |
 y v ma-l; mwh × y v ma-l F1 females (uric acid -) | |||||
  0 | 100 | 117 | 46 (0.39) | 11 (0.09) | 57 (0.49) |
  0.5 | 88 | 105 | 42 (0.40) | 9 (0.09) | 51 (0.49) |
  1 | 95 | 111 | 66 (0.59)* | 15 (0.14) | 81 (0.73)* |
  2 | 50 | 53 | 48 (0.91)** | 4 (0.08) | 52 (0.98)** |