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Table 2 Mutagenicity of MeIQx in urate-null mutants and wild-type flies

From: Increase of somatic cell mutations in oxidative damage-sensitive drosophila

Dose (mM) Survival (%) No. of wings No. of spots (spots/wing)
Small Large Total
Exp. 1
 y v ma-l; mwh × Oregon-R F1 females (uric acid +)
  0 100 143 11 (0.08) 6 (0.04) 17 (0.12)
  2 58 89 15 (0.19)* 5 (0.06) 20 (0.25)*
  4 80 126 41 (0.33)** 11 (0.09) 52 (0.41)**
 y v ma-l; mwh × y v ma-l F1 females (uric acid -)
  0 100 135 65 (0.48) 9 (0.07) 74 (0.55)
  2 62 84 63 (0.75)** 13 (0.15) 76 (0.90)**
  4 68 92 90 (0.98)** 29 (0.32)** 119 (1.29)**
Exp. 2
 y v ma-l; mwh × Oregon-R F1 females (uric acid +)
  0 100 151 19 (0.13) 4 (0.03) 23 (0.15)
  0.5 68 92 11 (0.12) 6 (0.07) 17 (0.18)
  1 67 108 31 (0.29)** 5 (0.05) 36 (0.33)**
  2 57 94 28 (0.30)** 8 (0.09) 36 (0.38)**
 y v ma-l; mwh × y v ma-l F1 females (uric acid -)
  0 100 117 46 (0.39) 11 (0.09) 57 (0.49)
  0.5 88 105 42 (0.40) 9 (0.09) 51 (0.49)
  1 95 111 66 (0.59)* 15 (0.14) 81 (0.73)*
  2 50 53 48 (0.91)** 4 (0.08) 52 (0.98)**
  1. *P ≤ 0.05, **P ≤ 0.01, a significant increase in comparison to the corresponding control