Table 3 Mutation frequency in the lacZ and cII genes from the liver of Muta™ mice treated with 2,5-, 2,6- and 3,5-DMAs
Animal ID | lacZ | cII | |||||||
|---|---|---|---|---|---|---|---|---|---|
Total plaquesa | Mutants | MF (× 106) | Mean ± SD | Total plaquesa | Mutants | MF (× 106) | Mean ± SD | ||
Control (olive oil) | 41 | 418,500 | 44 | 105.1 | 1,114,800 | 44 | 39.5 | ||
42 | 233,000 | 21 | 90.1 | 1,129,500 | 33 | 29.2 | |||
43 | 709,500 | 66 | 93.0 | 1,346,400 | 45 | 33.4 | |||
44 | 444,500 | 63 | 141.7 | 2,203,200 | 173 | 78.5 | |||
45 | 1,057,500 | 104 | 98.3 | 2,798,400 | 77 | 27.5 | |||
Total | 2,863,000 | 298 | 104.0 | 105.7 ± 18.7 | 8,592,300 | 372 | 43.3 | 41.6 ± 18.9 | |
2,5- DMA | 81 | 331,250 | 38 | 114.7 | 1,257,000 | 56 | 44.6 | ||
82 | 165,000 | 15 | 90.9 | 846,000 | 27 | 31.9 | |||
83 | 639,000 | 26 | 40.7 | 892,800 | 21 | 23.5 | |||
84 | 2,109,000 | 220 | 104.3 | 2,120,400 | 129 | 60.8 | |||
85 | (87000) | 10 | 114.9 | 129,000 | 6 | 46.5 | |||
Total | 3,348,750 | 310 | 92.6 | 87.7 ± 28.4 | 5,245,200 | 239 | 45.6 | 41.5 ± 12.8 | |
2,6- DMA | 91 | 573,000 | 72 | 125.7 | 1,473,600 | 41 | 27.8 | ||
92 | 840,000 | 76 | 90.5 | 2,028,000 | 72 | 35.5 | |||
93 | 2,826,000 | 230 | 81.4 | 945,000 | 25 | 26.5 | |||
94 | 2,435,000 | 193 | 79.3 | 3,013,800 | 164 | 54.4 | |||
95 | 131,250 | 11 | 83.8 | 612,000 | 11 | 18.0 | |||
Total | 6,805,250 | 582 | 85.5 | 92.1 ± 17.2 | 8,072,400 | 313 | 38.8 | 32.4 ± 12.3 | |
3,5- DMA | 101 | 1,053,000 | 100 | 95.0 | 2,167,200 | 72 | 33.2 | ||
102 | 277,500 | 24 | 86.5 | 1,095,000 | 30 | 27.4 | |||
103 | 2,111,000 | 170 | 80.5 | 2,426,400 | 95 | 39.2 | |||
104 | 2,723,000 | 234 | 85.9 | 2,522,400 | 129 | 51.1 | |||
105 | 1,641,000 | 184 | 112.1 | 1,960,800 | 71 | 36.2 | |||
Total | 7,805,500 | 712 | 91.2 | 92.0 ± 11.1 | 10,171,800 | 397 | 39.0 | 37.4 ± 7.9 | |